首页|麝香化学成分及抗肿瘤研究进展

麝香化学成分及抗肿瘤研究进展

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麝香作为一味用药历史悠久、药效确切的名贵中药材,具有较高的药用和经济价值。麝香主要含有大环酮类、吡啶生物碱类、甾体类、多肽蛋白质类、芳香族杂环类等化学成分。而对麝香及其成分的药理研究主要侧重于抗炎、强心和抗肿瘤等方面。此外,含麝香的中药复方制剂,如西黄丸、六神丸、八宝丹在临床上应用广泛,主要用于抗肿瘤的辅助治疗。本文就麝香的化学成分、抗肿瘤作用、毒理作用及其复方制剂在防治肿瘤方面的临床应用进行归纳总结,旨在为麝香及其复方制剂的进一步开发利用及麝香抗肿瘤作用的深入研究提供参考。
Research Progress on Chemical Constituents and Anti-Tumor Effects of Musk
Musk is a valuable traditional Chinese medicine with a long history of medicinal use and proven efficacy,possessing significant medicinal and economic value.It primarily comprises macrocyclic ketones,pyridine alkaloids,steroids,polypeptide proteins,aromatic heterocycles,and other chemical constituents.Research on the pharmacology of musk and its constituents has mainly focused on its anti-inflammatory,cardio-tonic,and anti-tumor properties.Moreover,traditional Chinese medicine compound preparations that contain musk,such as Xihuang(西黄)Pill,Liushen(六神)Pill,and Babaodan(八宝丹),are widely used in clinical practice,particularly as adjuvant therapy for anti-tumor treat-ment.This review summarized the chemical constituents,anti-tumor and toxicological effects of musk,as well as the clinical applications of compound preparations of musk in cancer prevention and treatment,so as to provide guidance for the future development and utilization of musk and its compound preparations and encourage further investigation into its anti-tumor efficacy.

MuskMacrocyclic ketonesAnti-tumorTraditional Chinese medicine compoundXihuang(西黄)Pill

杨孟妮、李睿、李莉、赵军宁、谭蕊蓉

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成都中医药大学药学院/现代中药产业学院,成都 610041

四川省中医药转化医学中心,四川省中医药科学院,国家中医药管理局中药质量生物评价重点研究室,中医药转化医学四川省重点实验室,四川省道地药材系统开发工程技术研究中心,四川省道地药材形成原理与品质评价工程研究中心,成都 610041

电子科技大学医学院附属肿瘤医院,四川省肿瘤医院放疗中心,成都 610041

麝香 大环酮类 抗肿瘤 中药复方 西黄丸

四川省基本业务专项电子科技大学四川省肿瘤医院肿瘤医工创新基金

A-2022N-Z-2ZYGX2021YGCX020

2024

中药药理与临床
中国药理学会 四川省中医药科学院

中药药理与临床

北大核心
影响因子:0.996
ISSN:1001-859X
年,卷(期):2024.40(6)
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