Similarities and Differences in Medication Rules of Traditional Chinese Medicine in the Treatment of Vestibular Peripheral and Central Vertigo
Objective:To analyze the similarities and differences in medication rules of traditional Chinese medicine(TCM)in the treatment of ves-tibular peripheral vertigo(VPV)and vestibular central vertigo(VCV)based on the literature.Methods:CNKI,VIP,Wanfang Data,and Si-noMed were searched for clinical studies of TCM prescriptions in the treatment of VPV and VCV to establish a database of prescriptions.The high-frequency drugs and their effects were analyzed by data mining techniques(frequency statistics,association rules,and cluster analysis).Liquorice software was used to analyze the combination rules of core prescriptions,and the medication rules and characteristics were obtained.Results:A total of 535 clinical studies were included,including 243 on VPV and 292 on VCV.Frequency analysis results showed that the top five drugs for the treatment of VPV were Baizhu(白术),Banxia(半夏),Fuling(茯苓),Zexie(泽泻),and Gancao(甘草),and the top five drugs for the treatment of VCV were Chuanxiong(川芎),Tianma(天麻),Banxia,Gegen(葛根),and Baizhu.The top five effects in the treatment of VPV were Buqi(补气),Huatan(化痰),Lishuishenshi(利水渗湿),Pingganxifeng(平肝息风),and Wenyang(温阳),and the top five effects in the treatment of VCV were Huoxuequyu(活血祛瘀),Buqi,Pingganxifeng,Huatan,and Lishuishenshi.Association rules analysis showed that the top three drug pairs with the highest support in the VPV group were Baizhu-Banxia,Baizhu-Fuling,and Baizhu-Zexie,and those in the VCV group were Banxia-Tianma,Banxia-Baizhu,and Gegen-Chuanxiong.The top three drug pairs with the highest de-gree of confidence in the VPV group were Chenpi(陈皮)-Banxia,Zhuru(竹茹)-Banxia,and Guizhi(桂枝)-Fuling,and those in the VCV group were Chishao(赤芍)-Chuanxiong,Taoren(桃仁)-Chuanxiong,and Chenpi-Banxia.The cluster analysis of high-frequency drugs showed four and three prescriptions in the VPV and VCV groups,respectively.The complex network analysis showed that one core prescrip-tion was obtained in each group.Conclusion:Dizziness is the common clinical manifestation of VPV and VCV.The common core pathogene-sis elements include Qixu(气虚),Feng(风),Tan(痰),and Yu(瘀),and Tan and Feng are more critical.Therefore,the main therapeutic methods consist of Xifeng(息风),Huatan,Yiqi(益气),and Huoxue(活血).VPV focuses on Shuiyinneisheng(水饮内盛)and Qingy-angbusheng(清阳不升),and the drugs effective in Wenyanghuayin(温阳化饮),Shengyanglishui(升阳利水),and Heweizhiou(和胃止呕)are used.VCV focuses on Qixuxueyu(气虚血瘀)and Yinxufengdong(阴虚风动),and drugs potent in Yiqihuoxue(益气活血),Hua-yutongluo(化瘀通络),Buyiganshen(补益肝肾),and Ziyinxifeng(滋阴息风)are used.
万方数据
维普
