Medication Rules for Chronic Atrophic Gastritis with Intestinal Metaplasia Based on Data Mining
Objective:To analyze the medication rules of traditional Chinese medicine(TCM)in the treatment of chronic atrophic gastritis(CAG)with intestinal metaplasia(IM)to provide theoretical references for clinical treatment.Methods:CNKI,Wanfang Data,and VIP were searched for relevant literature on the treatment of CAG with IM.Excel database was established for descriptive statistics of high-frequency drugs,Xing(性),Wei(味),Guijing(归经),and syndrome elements.SPSS Statistics 23.0 was used for cluster analysis,SPSS Modeler 18.0 for association rule analysis,and Lantern 5.0 for hidden structure analysis.Results:A total of 165 research articles were included,involving 214 prescriptions,229 drugs with a total frequency of 2 642 times,and 47 core drugs with a frequency＞15,and Gancao(甘草),Baizhu(白术),Baishao(白芍),Banxia(半夏),and Fuling(茯苓)were widely used.According to the maximum dosage,common dosage,and mini-mum dosage,47 high-frequency drugs were analyzed.In terms of Xing and Wei,drugs were mainly Gan(甘)and Wen(温),and in terms of Guijing,drugs mainly acted on the Ganjing(肝经).Six syndrome elements on disease location were extracted,which were represented by Pi(脾),Wei(胃),and Gan(肝),and 12 syndrome elements on disease property were extracted,which were represented by Qixu(气虚),Xu-eyu(血瘀),and Qizhi(气滞).Association rule analysis was conducted with confidence＞85％,support＞10％,and lift＞1,and 11 triplet combinations of drugs were obtained.Association rule analysis was carried out on high-frequency drugs and high-frequency syndrome.The top 5 association combinations were screened from high to low according to the classification of syndrome with confidence＞90％,support＞2％,and lift＞1,and 40 association combinations were obtained.Forty-seven hidden variables and seven hidden classes were obtained from the a-nalysis of hidden structure,and five comprehensive clustering models were summarized.Conclusion:CAG with IM is common in Xushijiaza(虚实夹杂)syndrome,and Piweikuixu(脾胃亏虚)and Benxubiaoshi(本虚标实)syndrome are key to this disease.Clinical treatment is based on Jianpiyiwei(健脾益胃)and Fuzhengquxie(扶正祛邪).In terms of Xu(虚),Buyi(补益)methods should be employed,specif-ically,Jianpi(健脾),Yiwei(益 胃),Bushen(补肾),and Zifei(滋肺)for Fuzheng(扶正).In terms of Shi(实),Xie(泻)methods should be adopted,specifically,Lishi(利湿),Qingre(清热),Sanhan(散寒),Huayu(化瘀),and Jiedu(解毒)for Quxie(祛邪).
万方数据
维普
