Prescription Rules of Chinese Medicine in the Treatment of COPD Complicated with Respiratory Failure of Tanshizufei(痰湿阻肺)Syndrome Based on R Language
Objective:To explore the prescription rules of Chinese medicine in the treatment of chronic obstructive pulmonary disease(COPD)complicated with respiratory failure(RF)of Tanshizufei(痰湿阻肺)syndrome based on the R language data mining platform.Methods:Eight databases,including China National Knowledge Infrastructure(CNKI),Wanfang Data,China Science and Technology Journal Database(VIP),Chinese BioMedical Literature Database(CBM),PubMed,Cochrane Library,Embase,and Web of Science were searched for research articles on traditional Chinese medicine(TCM)in the treatment of COPD complicated with RF of Tanshizufei syndrome according to the pre-set inclusion and exclusion criteria from database inception to February 2022.Excel was used to extract information,and R language was used to mine and analyze the times of usage,frequency,dosage,correlation degree,clustering,and other aspects of Chinese medicine,and the medi-cation rules of Chinese medicine in the treatment of COPD combined with RF of Tanshizufei syndrome were analyzed in combination with times of usage and frequency of prescriptions.Results:A total of 1 357 articles were retrieved in this study,and 37 articles were finally in-cluded.Thirty-seven drugs were included,with cumulative times of usage of 196.Among them,there were five drugs with times of usage grea-ter than 5,with cumulative times of usage of 142,accounting for 72.45％,which were Fuling(茯苓)(30,15.31％),Juhong(橘红)(30,15.31％),Chenpi(陈皮)(29,14.80％),Houpo(厚朴)(28,14.29％),and Jiangbanxia(姜半夏)(25,12.76％).Thirty-seven drugs could be divided into 13 categories.In terms of frequency,the top 5 categories were drugs effective in Liqi(理气)(64,32.65％),Huatan(化痰),Zhike(止咳),and Pingchuan(平喘)(40,20.41％),Huashi(化湿)(33,16.84％),Lishui(利水)and Shenshi(渗湿)(32,16.33％),and Buyi(补益)(13,6.63％).Among them,the main drugs for Huatan,Zhike,and Pingchuan were those for Wenhuahantan(温化寒痰)(34,17.35％)and Zhike and Pingchuan(4,2.04％),and Buyi drugs were mainly Buqi(补气)drugs(11,5.61％).In terms of Xing(性),drugs were mainly Wen(温),Ping(平),and slightly Han(寒),and in terms of Wei(味),drugs were mainly Xin(辛),Ku(苦),and Gan(甘).In terms of Guijing(归经),drugs mainly acted on the Fei(肺),Pi(脾),and Wei(胃).Six prescrip-tions were involved,with cumulative times of usage of 38.The prescription with the highest frequency was Zaoshi(燥湿)Huatan Prescription(30,78.95％),followed by Erchen Decoction(二陈汤)(4,10.53％).Association rules and cluster analysis revealed the core drug combi-nations based on Fuling,Juhong,Chenpi,Houpo,and Jiangbanxia.Conclusion:In the treatment of COPD complicated with RF of Tanshizufei syndrome,Fuling,Juhong,Chenpi,Houpo,and Jiangbanxia are the core drugs,and the main treatment principles are Zaoshi,Huatan,Liqi,and Zhike.On this basis,drugs efficient in Yiqi(益气),Jianpi(健脾),Hezhong(和中),Kuanxiong(宽胸),and Sanjie(散结)are added to achieve better clinical curative effect.In the future,the formulation of TCM syndrome diagnosis and diagnosis standards for COPD complicated with RF can be further standardized,and relevant research on accurate treatment based on Bianzheng(辨证)can be further strengthened,so as to provide references for TCM Bianzheng and treatment of this disease.
Chronic obstructive pulmonary diseaseRespiratory failureTanshizufei(痰湿阻肺)syndromeR languageChinese medicine
万方数据
维普
