Research Progress in the Mechanism of Luteolin in Preventing and Treating Diabetes Mellitus
Diabetes mellitus,one of the chronic diseases that seriously threaten human health,is often accompanied by serious clinical complica-tions,such as diabetic cardiomyopathy,nephropathy,retinopathy,and neuropathy.Mining novel molecules from natural plants to treat diabetes and its complications has emerged as a hot topic in current research due to the adverse effects of western medicines.Luteolin is a natural fla-vonoid ubiquitous in a variety of plants such as fruits and vegetables,possessing anti-inflammatory,antioxidant,immunomodulatory and other pharmacological effects.Studies have confirmed that luteolin is effective in preventing diabetes and regulating blood glucose level.To well un-derstand the functioning mechanism of luteolin,this article reviews the studies about the prevention and treatment of diabetes in recent years and summarizes the mechanisms of luteolin in restoring pancreatic islet β cell function,mitigating insulin resistance,regulating lipid metabo-lism,inhibiting intestinal absorption of glucose and lipids,and suppressing oxidative stress and inflammation.Furthermore,this article pros-pects the application of luteolin in the treatment of diabetes mellitus,aiming to promote the development and utilization of this active ingredient in Chinese herbal medicines.
LuteolinDiabetes mellitusMechanism of actionInsulin resistanceLipometabolismGlycolipid absorptionOxidative stressInflammation
万方数据
维普
