Diabetes mellitus,one of the chronic diseases that seriously threaten human health,is often accompanied by serious clinical complica-tions,such as diabetic cardiomyopathy,nephropathy,retinopathy,and neuropathy.Mining novel molecules from natural plants to treat diabetes and its complications has emerged as a hot topic in current research due to the adverse effects of western medicines.Luteolin is a natural fla-vonoid ubiquitous in a variety of plants such as fruits and vegetables,possessing anti-inflammatory,antioxidant,immunomodulatory and other pharmacological effects.Studies have confirmed that luteolin is effective in preventing diabetes and regulating blood glucose level.To well un-derstand the functioning mechanism of luteolin,this article reviews the studies about the prevention and treatment of diabetes in recent years and summarizes the mechanisms of luteolin in restoring pancreatic islet β cell function,mitigating insulin resistance,regulating lipid metabo-lism,inhibiting intestinal absorption of glucose and lipids,and suppressing oxidative stress and inflammation.Furthermore,this article pros-pects the application of luteolin in the treatment of diabetes mellitus,aiming to promote the development and utilization of this active ingredient in Chinese herbal medicines.
关键词
木犀草素/糖尿病/作用机制/胰岛素抵抗/脂肪代谢/糖脂吸收/氧化应激/炎症
Key words
Luteolin/Diabetes mellitus/Mechanism of action/Insulin resistance/Lipometabolism/Glycolipid absorption/Oxidative stress/Inflammation
维普
万方数据