The"Yinjing(引经)"theory is an important part of traditional Chinese medicine(TCM)theory,and based on this theory,ACHYRAN-THIS BIDENTATAE RADIX can guide other drugs in a formula to reach the affected site.Bone marrow mesenchymal stem cells(BMSCs)possess the ability of self-renewal,replication,repair,and multidirectional differentiation.Based on the"Yinjing"theory and focusing on mod-ern research,this article traced the origins,consolidated the foundation,and explored new developments.This article explored the mechanism of ACHYRANTHIS BIDENTATAE RADIX in promoting the migration of BMSCs via the"Yinjing"effect by examining the relationship be-tween the pharmacological effects of ACHYRANTHIS BIDENTATAE RADIX and BMSCs as well as the associated signaling pathways,and an-alyzing the correlation between the"Yinjing"effect of ACHYRANTHIS BIDENTATAE RADIX and the expression of proteins and transcrip-tion factors in the upstream and downstream of these pathways,thereby exerting the impact on the proliferation,differentiation,and migration of BMSCs.It fills the theoretical gap in previous studies that focused solely on the"Yinjing"theory or the migration of BMSCs.Moreover,a summary of the relationship among the"Yinjing"theory,signaling pathways,and stem cell migration was provided,laying the theoretical foun-dation for future clinical medication.
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