Efficacy of Modified Danzhixiaoyaosan(丹栀逍遥散)and Acitretin Capsules in Treating Psoriasis Vulgaris with Ganjingyure(肝经郁热)Syndrome:A Randomized Controlled Trial
Objective:To observe the clinical efficacy of modified Danzhixiaoyaosan(丹栀逍遥散)and acitretin capsules in the treatment of psori-asis vulgaris due to Ganjingyure(肝经郁热)syndrome.Methods:A total of 210 patients were randomized into 3 groups(n=70)by the random number table method.The traditional Chinese medicine(TCM),western medicine,and combination groups were treated with modified Danzhixiaoyaosan,acitretin capsules,and modified Danzhixiaoyaosan+acitretin capsules,respectively,for 4 weeks.The clinical indicators,percentages of CD4+T lymphocyte subsets,growth factors,and inflammation indicators in the serum and skin tissue were determined.The clinical efficacy,recurrence rate,and safety were compared among the three groups.Results:The total response rate was 98.6％in the combi-nation group,which was higher than that in the TCM group(82.1％)and the western medicine group(80.3％)(P＜0.05).Compared with those before treatment,the treatment in the TCM group and combination group lowered the psoriasis area and severity index(PASI),dermatol-ogy life quality index(DLQI),lesion thickness of skin,TCM syndrome scores,Th1,Th17,Th22,nerve growth factor(NGF),transforming growth factor-β1(TGF-β1),vascular endothelial growth factor(VEGF),procalcitonin(PCT),chemokine(C-C-motif)receptor 6(CCR6),nuclear factor kappa-KB(NF-κB),and monocyte chemotactic protein 4(MCP-4)levels(P＜0.05),while it elevated the Treg and epidermal growth factor(EGF)levels(P＜0.05).The treatment in the western medicine group lowered the PSAI,DLQI,lesion thickness of skin,TCM syndrome scores,NGF,TGF-β1,VEGF,PCT,and NF-κB levels and elevated the EGF level(P＜0.05).After treatment,the combination group had lower PSAI,DLQI,lesion thickness of skin,NGF,TGF-β1,VEGF,PCT,NF-κB,and MCP-4 levels and higher EGF level than the TCM group(P＜0.05).Moreover,the combination group had lower PSAI,DLQI,lesion thickness of skin,TCM symptom scores,Th1,Th17,Th22,NGF,TGF-β1,VEGF,PCT,CCR6,NF-κB,and MCP-4 levels and higher Treg and EGF levels than the western medicine group(P＜0.05).The recurrence rate followed the trend of combination group＜TCM group＜western medicine group(P＜0.05).The incidence of adverse reactions was in an order of TCM group＜combination group＜western medicine group(P＜0.05).Conclusion:Modified Danzhixi-aoyaosan can reduce the degree of skin lesions and recover the levels of CD4+T lymphocyte subsets,growth factors,and inflammation indicators in the patients with psoriasis vulgaris due to Ganjingyure syndrome,with low recurrence rate and high safety.The combination of modified Danzhixiaoyaosan with acitretin capsules has the effect of increasing efficiency and reducing toxicity.
Modified Danzhixiaoyaosan(丹栀逍遥散)Acitretin capsulesPsoriasis vulgarisGanjingyure(肝经郁热)syndromeIncreas-ing efficiency and reducing toxicity
万方数据
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