Medication Laws of Professor Shi Wei in Treating Adenomyosis Based on Data Mining
Objective:To explore the medication Laws of Professor Shi Wei in treating adenomyosis(AM)based on data mining.Methods:The medical records of AM patients who received treatment in Professor Shi Wei's specialist clinic in the Affiliated Hospital of Shandong Universi-ty of Traditional Chinese Medicine from May 1,2020 to May 31,2023 were collected.A prescription library was established in Excel,and SPSS Modeler 18.0 and SPSS Statistics 25.0 were used for complex network analysis,bivariate and trivariate association analyses,and systematic clustering on the drugs in the prescriptions.Results:The clinical records of 254 AM patients were included,from which 768 valid prescriptions were collected.The prescriptions involved 174 Chinese medicines,with a total frequency of 15 827.The most commonly used Chinese medicines used by Professor Shi Wei for treating AM were Gancao(甘草),Huangqi(黄芪),Chishao(赤芍),Fuling(茯苓),Zao-jiaoci(皂角刺),Chonglou(重楼),Guizhi(桂枝),Taoren(桃仁),Moyao(没药),and Mudanpi(牡丹皮).In terms of medicinal prop-erties,cold,warm,and plain Chinese medicines were commonly used with high frequency.In terms of medicinal tastes,the Chinese medicines with sweet,bitter,and pungent tastes had high frequency.In terms of meridian tropism,the Chinese medicines with tropism to the liver,heart,and spleen meridians had high frequency.Regarding the medicinal functions,the Chinese medicines with the functions of Buxu(补虚)and Huoxuehuayu(活血化瘀)were commonly used.The complex network analysis showed that the core prescription was modified from Guizhi-fuling(桂枝茯苓)Pills combined with Huangqijianzhong(黄芪建中)Decoction and Mojie(没竭)Powder.The systematic clustering of high-frequency Chinese medicines yielded five medicine combinations.Conclusion:Professor Shi Wei believes that AM is rooted in Yangx-uxueyu(阳虚血瘀)and located in Chongren(冲任)and Baogong(胞宫).The disease evolves as the Qi(气)and blood change and pres-ents as pain syndrome and blood syndrome.In treating AM,Professor Shi Wei follows the principle that when half of the disease is reduced,the use of drugs should be stopped,and chooses the methods of Pingxin(平心),Tiaogan(调肝),and Jianpi(健脾).He emphasizes the balance of Chongren(冲任)and Qixue(气血)and the restoration of organ functions.The medication used is aimed at balancing the cold,warm,and plain properties,which treats the Xie(邪)while Fuzheng(扶正),with focuses on Yiqihuoxue(益气活血)and Quyuxiaozheng(祛瘀消癥).In clinical practice,Professor Shi Wei is skilled at modifying classical prescriptions according to different cases,advocating simple and effective treatment.Moreover,he carefully examines the syndromes and implements treatment in stages according to the pathogene-sis.
Data miningAdenomyosisMedication lawsProfessor Shi Wei
万方数据
维普
