Research Progress in Chinese Medicine Intervention in Membranous Nephropathy-Associated Signaling Pathways
Membranous nephropathy (MN) is one of the most common causes of nephrotic syndrome in adults.At present,hormones,immunosup-pressants,and cytotoxins commonly used in the clinical treatment of MN are widely criticized for adverse reactions,side effects,and high recur-rence rate.Therefore,it is of great significance to update the current drugs and therapeutic options.Studies have shown that nuclear transcrip-tion factor-κB (NF-κB),nuclear factor erythroid 2-related factor 2 (Nrf2)/hemoglobin oxygenase-1 (HO-1),and the signaling pathways as-sociated with the regulation of cell cycle,the promotion of cell proliferation and differentiation (extracellular signal-regulated kinase (ERK) and the regulation of autophagy[e.g.,AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) and phosphatidyli-nositol-3 kinase (PI3K)/protein kinase B (Akt)/mTOR]are closely related to the occurrence and development of MN.In addition,studies have confirmed that Chinese medicine can regulate the deposition of immune complexes such as IgG,alleviate podocyte injury,promote podo-cyte autophagy,and reduce oxidative stress and inflammatory response by modulating related signaling pathways,thereby preventing and trea-ting MN.With high safety,good tolerance,multiple targets,low recurrence rate,and definite therapeutic effect,Chinese medicine can update the current drugs and therapeutic options for MN.By reviewing the latest research reports at home and abroad,this paper introduces the roles of the above-mentioned signaling pathways in the occurrence and development of MN and the recent research progress in the intervention of MN by Chinese medicine via these pathways,aiming to provide new ideas and directions for the in-depth study of MN prevention and treatment and provide a theoretical basis for the clinical application of traditional Chinese medicine in the prevention and treatment of MN.
Membranous nephropathyNephrotic syndromePodocytesTraditional Chinese medicineSignaling pathway
NETL
NSTL
万方数据
