Clinical Efficacy of Qihuang Jianpi Zishen Granules(芪黄健脾滋肾方)in Treating Patients with Systemic Lupus Erythematosus
Objective:To observe the clinical efficacy of Qihuang Jianpi Zishen Granules(黄健脾滋肾方)in the treatment of patients with sys-temic lupus erythematosus(SLE).Methods:Sixty patients with SLE were assigned into an observation group(n=30)and a control group(n=30)by the random number table method.The control group received basic treatment,and the observation group received basic treatment combined with Qihuang Jianpi Zishen Granules.The treatment in both groups lasted for 12 weeks.The clinical efficacy,TCM symptom scores,disease activity index(SLEDAI),physician's global assessment(PGA)score,and British Isles lupus assessment group(BILAG)in-dex,white blood cell count(WBC),red blood cell count(RBC),hemoglobin(HGB),platelet count(PLT),hematocrit(HCT),mean eryth-rocyte volume(MCV),reticulocyte count(RET),immunoglobulin G(IgG),Immunoglobulin A(IgA),immunoglobulin M(IgM),comple-ment 3(C3),complement 4(C4),cystatin C(CysC),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),vascular endothelial growth factor(VEGF),and safety index were determined.Results:Compared with those before treatment,the SLEDAI score,PGA score,BI-LAG index,TCM symptom scores(dizziness,tinnitus,facial erythema,hair loss,reduced appetite,and waist and knee soreness),and IgG,IgA,Cysc,ESR,VEGF,and CRP levels declined(P＜0.05),while the levels of WBC,RBC,HGB,PLT,HCT,MCV,RET,IgM,C3,and C4 elevated(P＜0.05)in the two groups after treatment.After treatment,the observation group had lower SLEDAI score,PGA score,BILAG in-dex,TCM syndrome scores(fatigue,dizziness and tinnitus,facial erythema,hair loss,insomnia and dreamful sleep,reduced appetite,waist and knee soreness,and dry stool),inflammation indicator levels(ESR,CRP,and VEGF),IgG,IgA,and CysC(P＜0.05)and higher levels of WBC,PLT,RBC,HCT,MCV,C3,and C4 than the control group(P＜0.05).The observation group had higher total response rate(93.33％vs.60.0％,P＜0.05)and higher safety than the control group.Conclusion:Qihuang Jianpi Zishen Granules combined with methylpred-nisolone and hydroxychloroquine sulfate have definite efficacy in recovering the clinical indicators including SLEDAI,demonstrating a great application value in clinical practice.
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