Animal Models Analysis of Cataracts Based on Clinical Evidence Characteristics of Chinese and Western Medicine
In recent years,the incidence of cataracts has been increasing year by year,which seriously endangers the visual health of human beings.To further understand the pathogenesis of cataracts and obtain effective prevention and treatment methods,this paper compiled animal models for reference based on western and Chinese medical etiology and pathogenesis of cataract,clinical diagnostic criteria,and animal model evalua-tion indexes.It was found that most of the animal models of cataracts were western medicine-oriented single etiology models,and the agree-ment between the modeling Results and clinical diagnostic criteria was generally moderate.The most commonly used streptozotocin(STZ)-in-duced models and galactose-induced models had a good match with the syndrome of Shenxu(Kidney deficiency)of cataracts in traditional Chinese medicine(TCM)and were widely used for Chinese and western drug screening,drug evaluation,and mechanism research.In addi-tion,the composite factor models had a short modeling time and high success rate,which were often used in basic research of etiology and dis-ease mechanisms.However,there were no TCM-guided models of cataracts,models combining disease and evidence were few,and there were large differences between model evaluation indexes and clinical diagnosis indexes of Chinese and western medicine.This paper analyzed the characteristics and shortcomings of animal models of cataracts and proposed improvements to provide references for the preparation of a feasi-ble and scientific model of cataracts combining Chinese and western disease and evidence.
CataractsAnimal modelsChinese and western medicine diagnosisDisease and evidence combinationWeighting indexStrepto-zotocinD-galactose
NETL
NSTL
万方数据
