Exploring Syndromes Based on Microscopic Indicators for Pishenyangxu(脾肾阳虚)Syndrome and Animal Models:A Review
Exploring syndromes based on microscopic indicators is a common research method in modern medicine.Pishenyangxu(脾肾阳虚)is a common clinical syndrome in multi-system diseases,and establishing the animal models is an important means to study this syndrome.Patho-logical modeling and etiological modeling are to major methods for the research on Pishenyangxu syndrome.The specific modeling methods in-clude purgation with hormones and Chinese medicines,hypothyroidism,surgical castration,and purgation with Chinese medicines combined with auxiliary stimulation.The last method has the most promising prospect.Specifically,Fanxieye(番泻叶)or Dahuang(大黄)decoction is used for gavage,and rectal dilatation or mother-infant separation is the optimal method for auxiliary stimulation.This paper systematically reviews the articles involving the biochemical indicators,imaging manifestations,genomics,proteomics,and metabonomics of Pishenyangxu syndrome.The recent studies about this syndrome mainly focus on the combination of disease and syndrome,and the simple research on syn-drome remains to be carried out.This review provides a reference for the future research direction on Pishenyangxu syndrome.
Pishenyangxu(脾肾阳虚)syndromeAnimal modelExploring syndromes based on microscopic indicatorsMicroscopic syn-drome differentiationMetabonomicsGenomics
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