Effect of Xianlu Xiaopi Capsules on the Mammary Gland Hyperplasia in Mmice Sex Hormones and Hypothalamic DA and MAO Content
To observe the effect of Xianlu Xiaopi capsules on cyclomastopathy in rats and its mechanism. Methods All unpregnancy female Wistar rats were randomly divided into blank control group (group 1) , model group (group 2) ,tamoxifen group (group 3) , and high -dose, mid - dose and low - dose Shugantongluo Formula group. The rat model of cyclomastopathy was established by injecting benzoate estradiol and progestogen intramuscularly for 30 days. The histo-morphological changes of mmmnmy glands, uterus and ovary, and the quantity and diameter of mammary lobule and alveolus were observed. The serum levels of estradiol ( E2) , progesterone ( P) , Head issuing grave neurotransmitter dopamine ( DA) , Monoamine oxidase(MAO) the influence of the content in mammary glanas were detected. Results;In high group of Xianlu Xiaopi capsules, the serum E2 level was decreased with a significant difference. The level of P was increased with a significant difference compared with model group. Raise head issueing grave neurotransmitter DA content, inhibit the content of MAO . Conclusion: Xianlu Xiaopi capsules have a therapeutic effect on cyclomastopathy in rats through affecting mammary gland hyperplasia mice Serum E2, P content and head issueing grave DA, MAO content and from the whole adjustment hypothalamus - pituitary - adrenal axis ovarian, treatment of mammary gland hyperplasia.
Proliferation of mammary glandXianlu Xiaopi capsuleHypothalamic neurotransmittersE2P
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