Historical Evolution and Modern Clinical Application Analysis of Six-Ingredient Rehmannia Pill in Pediatrics
This study aims to review the historical development and modern clinical applications of Six-Ingredient Rehmannia Pill in pediatrics.Using bibliometric methods,we retrieved literature on the application of Six-Ingredient Rehmannia Pill in pediatrics from databases such as the Chinese Medical Classics,TCM Classic Sea,and CNKI.We analyzed its historical origins,composition,efficacy,indications,and modern clinical applications.The results indicate that from the Song Dynasty to the Qing Dynasty,the dosage of Ze Xie(Alisma),Mu Dan Pi(Moutan Cortex),and Fu Ling(Poria)in Six-Ingredient Rehmannia Pill increased,while the dosages of Shu Di Huang(Rehmannia),Shan Yao(Dioscorea),and Shan Zhu Yu(Cornus)remained relatively stable.The primary efficacy shifted from liver and kidney tonification in the Song Dynasty to a balanced approach of tonification and heat-clearing in the Ming and Qing Dynasties.Its clinical indications have become increasingly diverse.Modern clinical applications indicate that Six-Ingredient Rehmannia Pill is frequently used in pediatrics for treating respiratory diseases,followed by urinary,endocrine,and neurological system diseases.This comprehensive review of ancient and modern literature on Six-Ingredient Rehmannia Pill in pediatrics aims to provide references for its broader clinical application and further research.
Six-Ingredient Rehmannia PillHistorical evolutionChinese medical classicsLiterature researchClinical application