Clinical Observation on the Therapeutic Effect of Modified Huanglian Wendan Decoction in Patients with Phlegm-Dampness Congestion Syndrome of Metabolic Syndrome
Objective:To observe the clinical efficacy of modified Huanglian Wendan Decoction in treating patients with phlegm-dampness Congestion syndrome of metabolic syndrome(MS).Methods:A total of 68 patients diagnosed with phlegm-dampness Congestion type MS who visited the Department of Cardiology at The First Affiliated Hospital of Heilongjiang University of Chinese Medicine from September 2021 to September 2022 were selected.Patients were randomly divided into two groups:the control group and the treatment group,with 34 patients in each group.The control group received conventional Western medicine treatment along with health education,while the treatment group received the same treatment as the control group,plus modified Huanglian Wendan Decoction.Both groups underwent a 6-week treatment period.The efficacy of TCM syndromes,as well as various indicators including blood pressure(diastolic and systolic),waist circumference,blood glucose[homeostasis model assessment of insulin resistance(HOMA-IR),fasting insulin(FINS),fasting blood glucose(FPG)],body mass index(BMI),and blood lipid levels[high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),total cholesterol(TC),triglycerides(TG)]were compared before and after treatment.Results:After 6 weeks of treatment,waist circumference,diastolic and systolic blood pressure,HOMA-IR,FINS,FPG,LDL-C,TC,TG,and BMI were significantly lower in both groups(P<0.05),with the treatment group showing significantly better results than the control group(P<0.05).HDL-C levels were significantly higher than before treatment in both groups(P<0.05),and the treatment group had significantly higher HDL-C compared to the control group(P<0.05).The total effective rate of TCM syndrome treatment in the treatment group was 94.1%(32/34),significantly higher than 79.4%(27/34)in the control group(P<0.05).Conclusion:Modified Huanglian Wendan Decoction is effective in improving the symptoms of phlegm-dampness Congestion type MS,and it can reduce waist circumference,blood pressure,BMI,blood lipids,and blood glucose levels.