中医药学报2025,Vol.53Issue(1) :111-117.DOI:10.19664/j.cnki.1002-2392.250020

白花蛇舌草抗肿瘤的药理机制及药代动力学研究进展

Pharmacological Mechanisms and Pharmacokinetic Research Progress of the Antitumor Effects of Hedyotis Diffusa

张宇飞 李力恒 陈昌瑾 李依诺 袁有才
中医药学报2025,Vol.53Issue(1) :111-117.DOI:10.19664/j.cnki.1002-2392.250020

白花蛇舌草抗肿瘤的药理机制及药代动力学研究进展

Pharmacological Mechanisms and Pharmacokinetic Research Progress of the Antitumor Effects of Hedyotis Diffusa

张宇飞 1李力恒 2陈昌瑾 1李依诺 1袁有才1
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作者信息

  • 1. 黑龙江中医药大学,黑龙江哈尔滨 150040
  • 2. 黑龙江中医药大学,黑龙江哈尔滨 150040;黑龙江省中医药信息学重点实验室,黑龙江哈尔滨 150040
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摘要

白花蛇舌草具有清热解毒、消痈散结、利水通淋之功,环烯醚萜类、总黄酮类及蒽醌类等是发挥抗肿瘤作用的主要化学成分,对肺癌、肝癌、乳腺癌、结直肠癌等均有明显的抑制作用,其机制与抑制肿瘤细胞增殖、诱导肿瘤细胞凋亡等密切相关.目前对白花蛇舌草的药代动力学研究主要涉及个别单体成分,无法全面反映其药代动力学特征,故本文检索国内外数据库,对近年来白花蛇舌草抗肿瘤作用、药代动力学的研究现状作一综述,旨在为后续采用多成分整合方法研究其体内药代动力学奠定基础,并为其研究开发及临床应用提供一定的参考.

Abstract

Hedyotis diffusa has the effects of clearing heat and detoxifying,reducing abscesses,and dissipating nodules.Flavonoids and terpenoids are its main chemical components that exert antitumor effects,showing significant inhibitory effects on lung cancer,liver cancer,breast cancer,colorectal cancer,etc.Its mechanisms are closely related to the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis.Current pharmacokinetic research on Hedyotis diffusa mainly involves individual monomer components and cannot fully reflect its pharmacokinetic characteristics.This article reviews the recent research status of the antitumor effects and pharmacokinetics of Hedyotis diffusa by searching Chinese and English databases at home and abroad.The aim is to lay a foundation for subsequent research on the pharmacokinetic behavior of Hedyotis diffusa using a multi-component integration method and to provide a reference for the research,development,and clinical application of Hedyotis diffusa.

关键词

白花蛇舌草/抗肿瘤/药理作用/药代动力学

Key words

Hedyotis diffusa/Antitumor/Pharmacological effects/Pharmacokinetics

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出版年

2025
中医药学报
中华中医药学会,黑龙江中医药大学

中医药学报

CSTPCD
影响因子:1.169
ISSN:1002-2392
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