We introduce various methods and mechanism of animal models about inflammation including non - specificity inflammation model, infective inflammation model and abnormal reactive inflammation model according to cause of disease. We simulates different pathology period in the Non - specificity inflammation model including capillary permeability model, swelling of ear, forced foot model and granuloma model. The abnormal reactive inflammation model includes adjuvant - induced arthritis, contact dermatitis and aerostat synovitis model. All in all, we consider it a premise on accomplishing the experiment for us to select more suitable model in different medicine experiments.