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雷公藤提取物对正常小鼠免疫功能的影响

Effect Study of Tripteryglum Wilfordii on Immune Function of Rat

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目的:通过观察雷公藤各提物对正常小鼠免疫功能的影响,探讨雷公藤抑制免疫与剂量的关系.方法:以生理盐水作为空白对照,以环磷酰胺作为抑制免疫研究的阳性对照,对雷公藤的石油醚、乙酸乙酯、乙醇及水溶部位的提取物首次进行药理学筛选,通过观察其对小鼠腹腔巨噬细胞吞噬功能的影响,检测其胸腺和脾脏的病理改变.观察雷公藤各提物对正常小鼠免疫功能的影响.结果:以大剂量的雷公藤乙酸乙酯和醇提物抑制免疫作用最强,与环磷酰胺的作用相似.小剂量雷公藤乙酸乙酯和醇提物还能增强正常小鼠腹腔巨噬细胞的吞噬功能.结论:雷公藤提取物抑制免疫的作用与剂量有关.
Objective: Inquiring into the dosage of restraining immunity in Tripteryglum wilfordii through observing the effect of Tripteryglum wilfordii on immunity of mice. Method: Take the Physiological Saline as blank group,and the cyclophosphamide as the controlgroup, select active constituent form Tripteryglum wilfordii and the materials extracted by bghtpetroleum, ethyl acetate, ethanol by the way of pharmacology. We study the effect of Tripteryglum wilfordii on normal mice by observing the following these indexes such as this model mice general action,mice abdominal cavity macrophages function of deglutition,the pathological changes of thymusand spleen. Results: Thebigdosage of Tripteryglum wilfordii ex-tractfrom ethylacetate and ethanol have the best effect on restraining immunity,the same ascyclophosphamidc,the small dosage of them also have the effect on enhancing the abdominalcavity macrophages flmction of deglutition. Conclusion: The effect of Tripteryglum wilfordii Oil restraining immunity related with the dosage.

triptetyglum wilfordiiimmune suppressiorat

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河南大学淮河医院,河南,开封,475000

雷公藤 免疫抑制 小鼠

2008

中华中医药学刊
中华中医药学会 ,辽宁中医药大学

中华中医药学刊

CSTPCD
影响因子:1.007
ISSN:1673-7717
年,卷(期):2008.26(9)
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