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基于TLR-4信号通路的中药防治急性肺损伤的研究进展

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急性肺损伤(acute lung injury,ALI)为临床常见的急危重症,发病机制复杂,病死率较高。Toll受体4(Toll-like receptor 4,TLR-4)信号通路与炎症反应密切相关,在ALI的发病机制中起着重要的作用。近年来,研究发现一些中药复方及活性成分通过调节TLR-4信号通路达到防治ALI的作用。就TLR-4信号通路及其在ALI中的作用,以及以该通路相关分子为靶点防治ALI中药的研究进展做一综述。
Progress of Traditional Chinese Medicine in Anti-Acute Lung Injury Effect Based on TLR-4 Signaling Pathway
Acute lung injury is clinical common critical disease and its pathogenesis is complicated and the mortality is high.Toll-like receptor 4 (TLR-4) signaling pathway is closely related to the inflammatory reaction and plays an important role in the pathogenesis of ALI.In recent years,studies have found that some traditional Chinese medicine compound and active ingredients could protect and treat ALI through regulating the TLR-4 signaling pathway.In this pa per,we reviewed TLR-4 signaling pathway,the role of TLR-4 in ALI and the research progress of traditional Chinesemedicine in the prevention and treatment of ALI via TLR-4 signaling pathway.

acute lung injuryTLR-4 signaling pathwayactive ingredientsingle herbChinese herbal compound

秦丽、李敏、窦永起

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解放军总医院中医医院,北京100853

急性肺损伤 TLR-4信号通路 活性成分 单味中药 中药复方

国家自然科学基金

81303131

2017

中华中医药学刊
中华中医药学会 ,辽宁中医药大学

中华中医药学刊

CSTPCD北大核心
影响因子:1.007
ISSN:1673-7717
年,卷(期):2017.35(4)
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