Effect of Xiaoying Sanjie Decoction(消瘿散结方)Combined with Levothyroxine Sodium Tablets on Thyroid Function and Nodular Size in Patients with Nodular Goiter
Objective To observe the effect of Xiaoying Sanjie Decoction(消瘿散结方)combined with levothyroxine sodium tablets on thyroid function and nodular size in patients with nodular goiter.Methods A total of 100 patients with nodular goiter ad-mitted to the Department of Traditional Chinese Medicine,Shanxi Provincial Peoples Hospital from July 2021 to July 2022 who met the inclusion and exclusion criteria were selected and divided into two groups by random number table method.Fifty cases in the conventional treatment group were given the levothyroxine sodium tablets and 50 cases in the Xiaoying Sanjie Decoction group were given Xiaoying Sanjie Decoction on the basis of the conventional treatment group.The clinical efficacy,size and number of thyroid nodules,psychological state and adverse reactions before and after intervention were compared between the two groups.Results The total effective rate of the conventional treatment group was 80.00％(40/50)and that of the Xiaoying Sanjie Decoc-tion group was 94.00％(47/50).The total effective rate of the Xiaoying Sanjie Decoction group was significantly increased(P＜0.05).After the completion of the intervention,the size and number of nodules and arterial blood flow parameters of the patients in the Xiaoying Sanjie Decoction group were significantly decreased compared with those in the conventional treatment group(P＜0.01).Compared with those of the conventional treatment group,there were no significant changes in the levels of,free triiodo-thyronine(FT3),free thyroxine(FT4)or thyroid hormone(TSH)before and after the intervention in the Xiaoying Sanjie Decoc-tion group(P＞0.05).Before intervention,there was no significant difference in Self Rating Anxiety Scale(SAS)or Self Rating Depression Scale(SDS)score between the two groups(P＞0.05).After the completion of intervention,the SAS score and SDS score of the patients in the Xiaoying Sanjie Decoction group were significantly lower than those in the conventional treatment group(P＜0.01).During the treatment,the main adverse reactions of the two groups were headache,palpitation,drug eruption,nausea and vomiting,etc.The total adverse reaction incidence of the conventional treatment group was 18.00％(9/50)and the that of the Xiaoying Sanjie Decoction group was 14.00％(7/50).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion The combination of levothyroxine sodium tablets and Xiaoying Sanjie Decoction can improve the clinical efficacy of nodular goiter(Qi stagnation and phlegm coagulation type),improve thyroid func-tion,reduce the number of nodules and reduce the volume of nodules.Its efficacy is superior to that of simple levothyroxine sodi-um treatment,and is suitable for clinical promotion.
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