Clinical Effect of Gegen Qinlian Decoction(葛根芩连汤)Combined with Mesalazine in Treatment of Damp-Heat Ulcerative Colitis of Large Intestine and Its Regulation of Intestinal Flora,Immune Function and Inflammation
Objective To observe the clinical effects of Gegen Qinlian Decoction(葛根芩连汤)combined with mesalazine in the treatment of damp-heat ulcerative colitis of large intestine and its regulatory effects on intestinal flora,immune function and inflammation.Method A total of 100 patients with ulcerative colitis treated in gastroenterology department of the hospital from Jan-uary 2020 to December 2022 were selected as research objects.According to random number table method,the patients were e-venly divided into mesalazine group and Gegen Qinlian Decoction group,with 50 cases in each group.Those in the mesalazine group were treated by oral mesalazine alone.Gegen Qinlian Decoction group was treated with mesalazine group and Gegen Qinlian Decoction.The clinical effects and adverse reactions of the two groups were observed,and the changes of serum inflammatory fac-tors,immune function and intestinal flora before and after intervention were compared.Results The effective rate was 80.00％(40/50)in mesalazine group and 94.00％(47/50)in Gegen Qinlian group.Compared with that of the mesalazine group,the ef-fective rate in Gegen Qinlian Decoction group was significantly higher(P＜0.05).After 4 weeks of intervention,compared with those of the mesalazine group,serum levels of IL-6,IL-8,IFN-γ and TNF-α in Gegen Qinlian Decoction were significantly decreased(P＜0.01).The levels of CD3+,CD4+and CD4+/CD8+in peripheral blood of Gegen Qinlian Decoction group were sig-nificantly increased,while the levels of CD8+were significantly decreased(P＜0.01,P＜0.05).The levels of intestinal bifidobacterium,lactobacillus and enterococcus in the Gegen Qinlian Decoction group were significantly higher than those in the mesalazine group,and the difference was statistically significant(P＜0.01).After 4 weeks of intervention,inflammatory bowel disease patient quality of life scale(IBDQ)score and the MOS item short from health survey(SF-36)score of the Gegen Qinlian Decoction group were significantly increased compared with those in the mesalazine group(P＜0.01).During treatment,the main adverse reactions in the two groups were abdominal distension,dyspepsia,dizziness,headache,fatigue,rash,etc.The total inci-dence of adverse reactions in mesalazine group and Gegen Qinlian Decoction group was 10.00％(5/50)and 14.00％(7/50),respectively,with no statistical significance(P＞0.05).Conclusion Gegen Qinlian Decoction combined with mesalazine can im-prove the clinical efficacy of patients with large intestine damp-heat ulcerative colitis,inhibit the serum inflammation and regu-late the immune function,and its mechanism is related to regulating the balance of intestinal flora in patients.
Gegen Qinlian Decoction(葛根芩连汤)ulcerative colitisdamp-heat in large intestineintestinal floraim-mune functioninflammation levelsclinical research
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