Some pungent herbs have analgesic effects and are divided into cold and warm types,and are used to treat heat pain or cold pain.ThermoTRP channels are cold and warm receptors,as well as nociceptors,expressed in sensory nerves.Cold and heat beyond the physiological range alarm in a painful way,which is the molecular insight of heat pain and cold pain.The pungent taste is a warning that plants drive away animals,and they sensitize ThermoTRP channels to produce pain,which can be divided into heat pain and cold pain.Continuous stimulation makes ThermoTRP channels no longer sensitive to pungent stimula-tion,and the pain signal weakens or subsides,resulting in analgesic effect.The desensitization of ThermoTRP channels by pun-gent herbs is the basic principle of its pain relief.It summarized some TCM regulators of ThermoTRP Channels(TRPV1,TRPM8,TRPA1)and explained the molecular mechanism of their pain relief.
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