非酒精性脂肪肝动物模型和疾病表型的研究进展
Research Progress on Animal Models and Disease Phenotypes of Non-alcoholic Fatty Liver Disease
宋丽 1熊伟 2胡宇 1兰昀羲 1唐宋琪 3贾波 1陈云慧 1张晓丹 1刘兴隆 1黄巍1
作者信息
- 1. 成都中医药大学,四川成都 611137
- 2. 成都岐黄博恩生物科技有限公司,四川成都 611139
- 3. 海南医学院,海南海口 571199
- 折叠
摘要
非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是一种以肝细胞脂肪堆积为特征的疾病,随着患病率的不断增高,NAFLD已成为全人类的健康问题.在NAFLD数十年的研究历史中,动物模型在发病机制、病理生理、治疗和预防的研究设计中发挥了不可替代的作用.NAFLD的动物模型种类繁多,按照动物的品种品系、造模时间和方法、造模判定指标进行总结,根据不同动物和方法得到的模型进行评估,比较模型与人类NAFLD的相似度和优缺点.
Abstract
Non-alcoholic fatty liver disease(NAFLD)is a disease characterized by the accumulation of fat in liver cells.With the increasing prevalence,NAFLD has become a health problem for all human beings.In the decades-long research history of NAFLD,animal models have played an irreplaceable role in the research design of pathogenesis,pathophysiology,treatment and prevention.There are many kinds of animal models of NAFLD,which are summarized according to the species and strains of ani-mals,modeling time and methods,and modeling judgment indicators.
关键词
非酒精性脂肪肝病/动物/模型/表型Key words
non-alcoholic fatty liver disease/animal/model/phenotype引用本文复制引用
基金项目
国家自然科学基金项目(81673879)
国家自然科学基金项目(82074329)
出版年
2024
国家科技期刊平台
NSTL
万方数据