Research Progress of Traditional Chinese Medicine in Intervention of Alzheimers Disease Based on Tau Protein Phosphorylation
Alzheimer's Disease(AD)is a kind of neurodegenerative disease characterized by progressive cognitive impairment and memory impairment.Hyperphosphorylation of Tau protein is one of the main pathogenesis of the disease.Tau protein is a mi-crotubule-associated protein mainly distributed in the axons of neurons in the central nervous system.Its hyperphosphorylation loses the ability to bind to microtubules,resulting in microtubule depolymerization,axonal transport disorders and the formation of Tau aggregation,which leads to neuronal apoptosis and the occurrence of AD.In recent years,studies have shown that traditional Chinese medicine can interfere with AD through multi-pathway and multi-target regulation of Tau protein phosphorylation.Based on the phosphorylation of Tau protein,this paper summarized the intervention of traditional Chinese medicine on AD,in or-der to provide reference for the prevention and treatment of AD.
Alzheimer's diseaseTau proteintraditional Chinese medicinetreatment
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