Research Progress on Treatment of Liver Cancer with Dahuang Zhechong Pill(大黄?虫丸)
Dahuang Zhechong Pill(大黄䗪虫丸),derived from Synopsis of The Golden Chamber,is a classic formula for treating diseases such as"deficiency,fatigue and dryness of blood".In recent years,it has been widely used in the comprehen-sive treatment of various malignant tumors,especially liver cancer.In this paper,the literature of nearly 20 years was searched and sorted out,the relevant research on the treatment of liver cancer by Dahuang Zhechong Pill was summarized from three as-pects:the characteristics of traditional Chinese medicine(TCM)formulation,clinical application and molecular mechanism.It is found that Dahuang Zhechong Pill in TCM has the characteristics of removing blood stasis by insects,nourishing deficiency by herbs,harmonizing liver and spleen,taking both liver and spleen into consideration,honeyed bolus making drastic herbs slowly and gently and so on,both the compatibility is rigorous and the medication is precise.In clinic,transcatheter arterial chemoembo-lizatio(TACE)and intravenous chemotherapy can reduce the adverse reactions,improve the clinical efficiency and prolong the survival time of patients.In addition,for patients with advanced primary liver cancer and liver metastases,single drug application can also significantly improve symptoms and the quality of life,and prolong the survival time of end-stage patients.The clinical efficacy is definite,and it also can be used for a long time with high safety.In the mechanism study,it is found that Dahuang Zhe-chong Pill has anti-liver cancer prelesion,protecting liver cells,regulating liver function,anti-liver cancer cell metastasis,in-hibiting tumor angiogenesis,promoting vascular normalization,regulating immunity and other related mechanisms.The molecular mechanism is clear.Through the above three aspects,this paper comprehensively elaborated the research status of Dahuang Zhe-chong Pill in the treatment of liver cancer and put forward the shortcomings and improvements of the current clinical and experi-mental studies,in order to provide ideas and basis for the subsequent in-depth research of this prescription and the development of new anti-tumor drugs.
Dahuang Zhechong Pill(大黄䗪虫丸)live cancerresearch progresstraditional chinese medicinereview
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