植物药总黄酮的药理作用机制及应用进展
Pharmacological Mechanism and Clinical Application of Total Flavonoids in Botanical drugs
李明奇 1赵晓璐 1高晓阳 1马月宏1
作者信息
- 1. 内蒙古医科大学基础医学院,内蒙古呼和浩特 010110
- 折叠
摘要
植物药总黄酮(total flavones,TF)包含的类型十分复杂,每种植物药所包含的总黄酮各不相同.植物药总黄酮具有多种药理学作用,包括对心血管系统的作用,能够保护缺血性心肌损伤(ischemic myocardial injury,ICM)以及抗高血压(hypertension,HBP).还能够保护肝脏和肾脏,对抗肝纤维化(hepatic fibrosis,HF),保护肾功能,另外对癌症和肿瘤也有一定的对抗作用.除此之外植物药总黄酮还具有调节代谢的药理学作用.凭借丰富的药理学作用,总黄酮逐渐受到现代药理学人员的重视,是中药方剂的重要成分,能够治疗高血压病以及病毒性感染所致的心肌损伤,也能够治疗药物性肝损伤(drug-induced liver injury,DILI)、终末期肝病(end stage liver disease,ESLD)及其并发症以及失代偿期 乙型肝炎肝硬化(decompensated hepatitis B cirrhosis)等肝脏疾病.在癌症的对抗中,能够抗肝癌(liver cancer)、甲状腺癌(thy-roid cancer,THCA)以及妇女晚期卵巢癌(advanced ovarian cancer)等多种癌症.在呼吸系统中能够治疗颈淋巴结炎(cer-vical lymphadenitis)、上呼吸道感染(upper respiratory tract infection,URTI)、急性扁桃体炎(acute tonsillitis)等.还能够治疗白癜风(vitiligo)和黄体功能不全型先兆流产患者等.总结植物药总黄酮药理作用机制及其临床应用情况,以期能够为后续研究和实践提供理论和信息基础.
Abstract
The types of total flavones(TF)in botanical drugs are very complex,and each botanical drugs contains different TF.TF in botanical drugs have a variety of pharmacological effects,including effects on the cardiovascular system,protection a-gainst ischemic myocardial injury(ICM)and anti-hypertensive(HBP).TF can also protect liver and kidney,relieve liver fibro-sis(HF)and protect kidney function,and have a certain anti-tumor effect.In addition,TF in botanical drugs also have regula-ting metabolism pharmacological effect.With rich pharmacological effects,TF have gradually been valued by modern pharmacolo-gists,and are important ingredients in traditional Chinese medicine formulae,which can treat myocardial damage caused by hyper-tension and viral infections,as well as drug-induced liver injuiy(DILI),end-stage liver disease(ESLD)and its complications,and decompensated hepatitis B cirrhosis and other liver diseases.In the fight against cancer,it can fight a variety of cancers such as liver cancer,thyroid cancer and advanced ovarian cancer in women.In the respiratory system,it can treat cervical lymphadeni-tis,upper respiratory tract infection,acute tonsillitis,etc.It can also treat vitiligo and luteal insufficiency threatened abortion pa-tients.This paper summarized the pharmacological mechanism of action of TF in botanical drugs and the clinical application,in order to provide a theoretical and information basis for subsequent research and practice.
关键词
总黄酮/药理作用机制/应用/心血管/肝纤维化Key words
total flavonoids/pharmacological mechanism/application/cardiovascular/liver fibrosis引用本文复制引用
基金项目
国家自然科学基金项目(81960759)
国家自然科学基金项目(81560706)
内蒙古自治区自然科学基金项目(2019MS08010)
内蒙古自治区自然科学基金项目(2014MS0841)
内蒙古自治区草原英才培养计划项目(2021-11-085)
内蒙古自治区草原英才培养计划项目(内组通字[2021]8号)
内蒙古人才开发基金项目(2022056)
内蒙古人才开发基金项目(内人社办发[2022]110号)
内蒙古医科大学致远人才项目(ZY0201012)
内蒙古医科大学致远人才项目(内医党发[2020]52号)
内蒙古医科大学蒙药抗肝纤维化作用研究科技创新团队项目(YKD2022ZD019)
内蒙古医科大学蒙药抗肝纤维化作用研究科技创新团队项目(内医校发[2022]36号)
出版年
2024
NETL
NSTL
万方数据