Effect of Wenyang Jianpi Huatan Decoction(温阳健脾化痰汤)in Treatment of Bronchiectasis and Changes of HNP1-3 and IL-17 in Patients
Objective To study the effect of Wenyang Jianpi Huatan Decoction(温阳健脾化痰汤)on bronchodilatation and the changes of alpha-defensin 1-3(HNP1-3)and interleukin-17(IL-17)in patients.Methods Eighty-six patients in re-mission stage of bronchiectasis in Zhuji People's Hospital from October 2020 to April 2022 were selected and randomly divided in-to two groups.The control group was treated with body position drainage,ambroxol hydrochloride tablets and other conventional treatments,while the decoction group was treated with Wenyang Jianpi Huatan Decoction for 4 consecutive weeks.The therapeutic effects of the two groups after 4 weeks of treatment were analyzed,and the differences in lung function,related serum factors,St.George's Respiratory Questionnaire(SGOR)scores and 6-minute walking distance(6MWT)between the two groups were detec-ted.Results After 4 weeks of treatment,the total effective rate of TCM symptoms in the decoction group was 90.70％(39/43),higher than that in the control group[74.42％(32/43)],with a difference(P＜0.05).There was no difference in pulmonary function between the two groups before treatment(P＞0.05).The levels of forced expiratory volume(FEV1)[(2.86±0.42)L],forced vital capacity(FVC)[(2.96±0.33)L]and FEV1/FVC[(60.47±6.89)％]in the decoction group at the first second after 4 weeks of treatment were higher than those in the control group(P＜0.05).There was no difference in the levels of HNP1-3,interleukin-2(IL-2),interleukin-8(IL-8)or IL-17 between the two groups before treatment(P＞0.05).After 4 weeks of treatment,the levels of other factors in the decoction group were lower than those in the control group(P＜0.05),ex-cept that the level of IL-2 was higher than that in the control group.There was no difference in SGOR score and 6MWT between the two groups before treatment(P＞0.05).After 4 weeks of treatment,the 6MWT[(394.11±70.14)m]in the decoction group was longer than that in the control group,and the SQRQ score[(12.41±3.65)point]was lower than that in the control group(P＜0.05).Conclusion Wenyang Jianpi Huatan Decoction can improve lung function,reduce inflammation and improve life quality and exercise endurance.
Wenyang Jianpi Huatan Decoction(温阳健脾化痰汤)bronchiectasisα-defensin 1-3inflammatory factorpulmonary function
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