Observation on Curative Effect of Different Moxibustion Quantities Warm Acupuncture Combined with Bitong Decoction(痹痛汤)in Treatment of Knee Osteoarthritis
Objective To explore the effect of different moxibustion quantities,number and temperature acupuncture combined with Bitong Decoction(痹痛汤)on knee osteoarthritis(KOA).Methods A total of 150 KOA patients admitted to the hospital from December 2018 to December 2020 were randomly divided into 3 groups with 50 patients in each group.They were all treated with warm acupuncture and moxibustion combined with Bitong Decoction on the basis of conventional Western medicine and reha-bilitation.The 1 moxibustion quantity group was treated with 1 moxibustion quantity warm acupuncture,2 moxibustion quantities group with 2 moxibustion quantities warm acupuncture,3 moxibustion quantities group with 3 moxibustion quantities warm acu-puncture.The clinical efficacy of all three groups was evaluated after 1 month of treatment.The joint function[Western Ontario and McMaster University Osteoarthritis Index(WOMAC)],cartilage repair factor[transforming growth factor-β(TGF-β),in-sulin-like growth factor-1(IGF-1)],serum inflammatory indexes[tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),Cyclooxygenase(COX-2)],hemorheology indicators[whole blood high shear viscosity(HBV),whole blood low shear viscosity(LBV),hematocrit(HCT)]and the occurrence of adverse reactions were observed during treatment.Results After 1 month of treatment,the effective rate of 3 moxibustion quantities group was 94.00％(47/50),the effective rate of 2 moxibustion quantities group was 92.00％(46/50),both of which were significantly higher than that of 1 moxibustion quantity group(74.00％,37/50),and the difference among the groups was statistically significant(P＜0.05),but there was no statistically sig-nificant difference between 3 moxibustion quantities group and 2 moxibustion quantities group(P＞0.05).After 1 month of treat-ment,the dimensions of WOMAC scale score,the levels of CRP,COX-2,HBV,LBV and HCT in the three groups were lower than those before treatment(P＜0.05),and the above indexes in the 3 and 2 moxibustion quantities groups were significantly low-er than those in the 1 moxibustion quantity group(P＜0.05),but there was no statistical significance between the 3 and 2 moxi-bustion quantities groups(P＞0.05).After 1 month of treatment,the levels of TGF-β in the three groups were increased com-pared with those before treatment(P＜0.05),the level of TGF-β in the 3 moxibustion quantities group was significantly higher than that in the 1 moxibustion quantity group(P＜0.05),and the level of TGF-β in the 2 moxibustion quantities group was sig-nificantly higher than that in the 1 moxibustion quantity group(P＜0.05),but there was no statistical significance between the 3 and 2 moxibustion quantities groups(P＞0.05).The level of IGF-1 in 2 moxibustion quantities group and 3 moxibustion quan-tities group was higher than that before treatment(P＜0.05),but there was no statistical significance between the two groups(P＞0.05).After 1 month of treatment,the levels of TNF-α,CRP and COX-2 in three groups were lower than those before treatment(P＜0.05),the level of TNF-α in 3 moxibustion quantities group was significantly lower than that in 2 moxibustion quantities group and 1 moxibustion quantity group(P＜0.05),and the level of TNF-α in 2 moxibustion quantities group was significantly lower than that in 1 moxibustion quantity group(P＜0.05).During treatment,there was no statistical significance in the total incidence of adverse reactions among the three groups(x2=0.196,P＞0.05).Conclusion Bitong Decoction combined with acupuncture and moxibustion of 2 quantities is beneficial to improve the symptoms and signs of patients and improve the clin-ical efficacy.The mechanism of action may be related to reducing inflammatory response,promoting cartilage repair and blood flow circulation.
different moxibustion quantitieswarm acupunctureBitong Decoction(痹痛汤)knee osteoarthritiscurative effect
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