Effect of Rosuvastatin Combined with Qishen Yiqi Dripping Pill(芪参益气滴丸)on Hypertension Complicated with Coronary Atherosclerotic Heart Disease and Its Influence on Arterial Plaque
Objective To observe the effect of rosuvastatin combined with Qishen Yiqi Dripping Pill(芪参益气滴丸)on hy-pertension complicated with coronary atherosclerotic heart disease and its influence on arterial plaque.Methods A total of 120 pa-tients with hypertension combined with coronary atherosclerotic heart disease from January 2021 to December 2021 were selected as the research subjects,and they were equally divided into the observation group and the control group by the random number method.The patients in the two groups were given anti-platelet aggregation and rosuvastatin stable plaque treatment.On this basis,the observation group was treated with Qishen Yiqi Dropping Pill.The clinical efficacy,cardiac function,blood lipid levels,carotid plaque and adverse reaction were compared between the two groups.Results The total effective rate in the observation group was significantly higher than that in the control group(P＜0.05).With the prolongation of treatment time,the values of left ventricular ejection fractions(LVEF)and left ventricular end-diastolic dimension(LVEDD)of patients in the two groups gradu-ally improved(P＜0.05).The values of LVEF and LVEDD in the observation group were higher than those in the control group on day 14 and 3 months after treatment(P＜0.05).After treatment,the levels of triglycerides,serum total cholesterol,low density lipoprotein cholesterol,homocysteine and C-reactive protein were gradually improved in both groups(P＜0.05).The levels of triglycerides,serum total cholesterol,low density lipoprotein cholesterol,homocysteine and C-reactive protein in the observation group were lower than those in the control group 3 and 6 months after treatment(P＜0.05).The values of carotid intima-media thickness(IMT)and the proportion of unstable plaques in the two groups gradually decreased after treatment(P＜0.05).The proportion of IMT unstable plaques in the observation group was lower than that in the control group 3 and 6 months after treat-ment(P＜0.05).There was no difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclu-sion Rosuvastatin combined with Qishen Yiqi Dripping Pill could better promote the recovery of patients with acute myocardial in-farction of hypertension with carotid arteriosclerosis,achieve the standard of dyslipidemia faster and more effectively reduce the formation of carotid unstable plaques without increasing adverse reactions.
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