Effect of Erchen Decoction(二陈汤)Combined with Sanzi Yangqing Decoction(三子养亲汤)on Pulmonary Function,IFN-γ and ET-1 in Treatment of Chronic Obstructive Pulmonary Disease of Phlegm-Damp Accumulating in Lung Syndrome
Objective To explore the clinical effect of Erchen Decoction(二陈汤)combined with Sanzi Yangqing Decoction(三子养亲汤)on pulmonary function,interferon γ(IFN-y)and endothelin-1(ET-1)in the treatment of chronic obstructive pulmonary disease of phlegm-damp accumulating in lung syndrome.Methods Eighty-six patients with chronic obstructive pul-monary disease in the hospital from February 2019 to March 2022 were randomly classified into two groups,each with 43 cases.The control group received conventional therapy.Based on this,the observation group received Erchen Decoction combined with Sanzi Yangqing Decoction.The pulmonary function parameters,contents of oxidative stress-related products protein carbonyl(PC),8-hydroxylated deoxyguanosine(8-OHdG),malondialdehyde(MDA),IFN-γ and ET-1 were compared between two groups.Meantime,the disappearance time of clinical symptoms and the clinical efficacy were recorded in both groups.Results An increase was observed in forced expiratory volume in one second(FEV1),peak expiratory flow(PEF)and peak pres-sure(Ppeak)in both groups after treatment(P＜0.05).Ppeak of the observation group was larger than that of the control group(P＜0.05).The levels of PC,8-OHdG and MDA were decreased in both groups after treatment(P＜0.05),and the three indi-cators of the observation group were lower than those in the control group(P＜0.05).A reduction was detected in levels of IFN-γ and ET-1 in both groups after treatment(P＜0.05),and the two indicators of the observation group were lower than those of the control group(P＜0.05).The disappearance time of clinical symptoms of the observation group was faster than that of the control group(P＜0.05).The overall clinical efficacy was 83.72％(36/43)in the observation group,which was higher than 65.12％(28/43)in the control group,with statistical difference(x2=3.909,P=0.048).Conclusion Application of Erch-en Decoction combined with Sanzi Yangqing Decoction in the treatment of chronic obstructive pulmonary disease of phlegm-damp accumulating in lung syndrome can effectively ameliorate the pulmonary function,reduce the contents of protein related to oxidative stress,shorten the disappearance time of clinical symptoms,reduce the levels of IFN-γ and ET-1,and improve the clinical efficacy.
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