Influence and Effect of Xiaoer Xiaoshi Granule(小儿消食颗粒)on Related Factors in Children with Infantile Anorexia
Objective To analyze the effectiveness of Xiaoer Xiaoshi Granule(小儿消食颗粒)on infantile anorexia in chil-dren and explore its effect on serum trace elements and hemoglobin in children.Methods A total of 60 children with anorexia who visited Danzhou People's Hospital from January 2022 to July 2022 were selected and divided into conventional treatment group and Xiaoer Xiaoshi Granule group,with 30 cases in each group.The children in the conventional treatment group were treated with multi-enzyme tablets combined with ledextran zinc granules.The children in the Xiaoer Xiaoshi Granule group were treated with Xiaoer Xiaoshi Granule on the basis of the conventional treatment group.The clinical efficacy,TCM syndrome score and body weight of the two groups were observed,and the changes of gastrointestinal hormones,trace elements and hemoglobin levels in ser-um were compared before and after intervention.Results The effective rate of the conventional treatment group was 73.33％,and that of the Xiaoer Xiaoshi Granule group was 93.33％.The effective rate of the Xiaoer Xiaoshi Granule group was significantly better than that of the conventional treatment group(P＜0.05).After drug administration,the scores of major symptoms such as loss of appetite,abdominal distension and nausea in the Xiaoer Xiaoshi Granule group were significantly lower than those in the conventional treatment group(P＜0.01,P＜0.05).Compared with those before administration,the scores of loss of appetite,de-creased food intake,halitosis,nausea,vomiting,dry stool,foul odor,tiredness and thirst in Xiaoer Xiaoshi Granule group after ad-ministration were significantly decreased(P＜0.05).After drug administration,the levels of pepsinogen Ⅰ,pepsinogen Ⅱ and gastrin were significantly increased,while the pro-gastrin-releasing peptide was significantly decreased in the Xiaoer Xiaoshi Granule group compared with those of the conventional treatment group(P＜0.01).After drug administration,compared with those of the conventional treatment group,the contents of serum Zn2+and Ca2+in the Xiaoer Xiaoshi Granule group were signifi-cantly increased(P＜0.05,P＜0.01).Before administration,there were no significant differences in hemoglobin or body weight between the two groups(P＞0.05).After drug administration,the values of hemoglobin(HGB)and body mass index(BMI)of children in the Xiaoer Xiaoshi Granule group were significantly increased compared with those in conventional treatment group(P＜0.01).Conclusion Xiaoer Xiaoshi Granule combined with conventional treatment can improve the clinical efficacy of chil-dren with anorexia,reduce the symptoms of traditional Chinese medicine,improve the body weight and serum hemoglobin and trace elements content and regulate the levels of gastrointestinal hormones in children.
NETL
NSTL
万方数据
