Research Progress on Effects oof Icariin on Digestive System Tumors and Its Mechanism
The poor prognosis and lack of effective drugs of digestive tract tumors is one of the main causes of human death.Yinyanghuo(Epimedii Folium)(Berberidaceae)has a long history as a traditional Chinese medicine for tonifying kidney and strengthening Yang.Modern studies have shown that Yinyanghuo(Epimedii Folium)and its main active component Icaritin(ICA)have multi-pathway and multi-target anti-tumor properties,and are promising anti-gastrointestinal cancer drugs.Acoradine,its patent drug,has shown good efficacy in patients with liver cancer and cervcal cancer.This article reviewed the re-search progress of ICA in digestive system tumors in recent years by reviewing the mechanisms of ICA regulating tumor cell cycle,inhibiting tumor cell proliferation and migration and regulating tumor immunity so as to accelerate the exploration and discovery of the molecular mechanisms of the pharmacological effects of ICA and provide a reference basis for clinical new drug development.
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