首页|兔儿风属植物化学成分及药理作用研究进展

兔儿风属植物化学成分及药理作用研究进展

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目的 对兔儿风属Ainsliaea植物的化学成分及其药理作用进行综述,以期为研究兔儿风属的化学成分并根据其药理作用为相关的新型药物提供思路与启发。方法 对近40年来大量国内外相关文献进行搜索与分析,并进行归纳整理与综述。结果 兔儿风属植物具有多种活性成分,该属植物化学成分主要包括倍半萜类、三萜类与甾体类化合物及其衍生物、酚酸类、黄酮类、蒽醌类、香豆素类、木脂素类、挥发油类等成分,其中倍半萜类成分主要包括愈创木烷型、吉玛烷型、桉叶烷型、多聚体倍半萜内酯等倍半萜类成分。此外,兔儿风属植物具有多种药理作用,主要涉及抗菌作用、抗炎作用、抗肿瘤作用、抗肥胖作用等方面。结论 兔儿风属植物药用历史悠久,具有多种化学成分与药理活性。目前的研究局限于兔儿风属植物的几个种,对兔儿风属植物质量控制的研究相对较少,可以考虑对该属的其他种植物进行相应的研究并综合研究成果规范该属植物质量控制的标准。现有的文献多局限于针对单一化合物在体内外活性机制的分析,对于其他种类化合物发挥药理作用及其机制的研究不够深入,有待进一步探索。
A Review of Chemical Constituents in Ainsliaea Plants and Their Pharmacological Activities
Objective To review the chemical constituents and pharmacological effects of the plants of the genus Ainsliaea,with the aim of providing ideas and suggestions for the study of the chemical constituents of the genus and the development of new drugs based on its pharmacological effects.Methods A large amount of domestic and foreign literature of the last 40 years was searched,analyzed and then summarized and reviewed.Results The plants of the Ainsliaea contains a variety of active com-pounds,including sesquiterpenoids,triterpenoids,steroidal compounds and their derivatives,phenolic acids,flavonoids,anthraqui-nones,coumarins,lignans,essential oils,etc.Sesquiterpenes mainly include guaiacane type,zimerane type,eucalyptane type,pol-ymer sesquiterpene lactone and other sesquiterpenes.In addition,the plants of the genus Ainsliaea have various pharmacological effects,which mainly include antibacterial,anti-inflammatory,anti-tumor,and anti-obesity effects.Conclusion The plants of the genus Ainsliaea have been used medicinally for a long time,and have various chemical components and pharmacological activ-ities.The current research is limited to some species of the plants of Ainsliaea,and there are relatively few studies on the quality control of the plants of Ainsliaea.It may be considered to conduct the corresponding research on other species of this genus and comprehensively standardize the quality control of this genus.The existing literature is mostly limited to the analysis of the in vivo and in vitro mechanisms of individual compound.The research of the pharmacological effects of other compounds and their mech-anisms is not deep enough and needs further research.

Ainsliaeasesquiterpenoidsantibacterialanti-inflammatoryanti-tumor

高苑、吕燕慧、徐希科、辛佳芸、杨美欣、林恬恬、陈佳、齐行睿、冯玉、祖先鹏

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山东中医药大学药学院,山东济南 250355

海军军医大学药学院,上海 200433

海军军医大学基础医学院,上海 200433

兔儿风属 倍半萜类 抗菌 抗炎 抗肿瘤

国家自然科学基金项目国家自然科学基金项目国家自然科学基金项目上海市卫生健康委员会卫生行业临床研究专项上海市中医药传承创新发展三年行动计划项目上海市扬帆计划项目上海市扬帆计划项目海军军医大学"深蓝"工程启航人才计划项目(2021)海军军医大学大学生创新能力培养计划项目海军军医大学大学生创新能力培养计划项目

82004215821412038200362420204Y0326ZY2021-2023-040120YF145870020YF1459000ZD2021022MS2021062

2024

中华中医药学刊
中华中医药学会 ,辽宁中医药大学

中华中医药学刊

CSTPCD北大核心
影响因子:1.007
ISSN:1673-7717
年,卷(期):2024.42(2)
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