New Progress in Research of Zhizichi Decoction(栀子豉汤)in Treatment of Depression
Depression is a clinically common emotional disorder with high incidence,relapse and suicide rates and other characteristics.The patients often show depression and slow thinking.Clinically,Western medicine has problems such as large side effects,low efficiency and poor patient compliance in the treatment of depression.Traditional Chinese medicine for the treat-ment of depression has the advantages of high safety,good efficacy,few side effects and high compliance.Zhizichi Decoction(栀子豉汤,ZZCD)is a classic formula in ZHANG Zhongjing's book Treatise on Febrile Diseases,which has the effects of relieving depression,clearing heat and purging fire.By searching the relevant literature on the treatment of depression in CNKI(China Na-tional Knowledge Internet),Wanfang Data,Pubmed,Web of Science and other databases,it is found that clinical application and experimental studies have confirmed that the treatment of depression is quite effective and experimental studies have shown that the antidepressant mechanism of ZZCD is mainly related to its ability to increase the contents of monoamine neurotransmitters in depression patients,reduce central and peripheral pro-inflammatory factors,regulate intestinal flora and protect nerve cells.This paper discussed the treatment of depression with ZZCD from three aspects:theory,clinical application and experimental research,so as to further study the new progress of ZZCD in the treatment of depression,in order to provide ideas and basis for clinical treatment of depression.
Zhizichi Decoction(栀子豉汤)depressionmechanism of actionreview
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