Research Progress of Traditional Chinese Medicine Intervention on Triple Negative Breast Cancer Related Signaling Pathway
As of 2022,breast cancer has become the most common cancer among women at home and abroad.Triple negative breast cancer(TNBC)refers to breast cancer with negative expressions of estrogen receptor(ER),progesterone receptor(PR)and human epidermalgrowth factor receptor-2(Her-2)by FISH or immunohistochemistry method.At present,chemotherapy with cytotoxic drugs is still the main treatment in Western medicine,such as anthracyclines and albumin-bound paclitaxel.Because of its high degree of malignancy and strong invasiveness,the 5-year survival rate is still low and the prognosis is poor.Revie-wing domestic and foreign literature,it is found that traditional Chinese medicine has definite curative effect and long-lasting effect on TNBC.Therefore,exploring the mechanism of traditional Chinese medicine in the treatment of TNBC has become a re-search hotspot in recent years.Previous studies have found that the formation of TNBC is related to Wnt/β-Catenin,nuclear fac-tor kappa-B(NF-κB),phosphatidylinositol 3-kinase(PI3K)-protein kinase B(AKT),Hedgehog,Notch,Hippo and other classical signal pathways.Traditional Chinese medicine can inhibit TNBC cell proliferation,migration,invasion,EMT formation,reverse drug resistance,promote apoptosis and other effects by interfering the above related signaling pathways,so as to achieve the purpose of anti-tumor.Based on cell signaling pathways,this paper summarized the domestic and foreign research status of TCM treatment of TNBC in recent years,aiming to provide reference for further study of TCM treatment of TNBC in the future and provide new ideas for clinical treatment of TNBC.
triple-negative breast cancersignal pathwaytraditional Chinese medicineresearch progress