目的 观察补肾健脾通络方治疗老年衰弱综合征临床疗效及安全性.方法 研究纳入2021年1月—2022年6月收治的老年衰弱综合征患者共计102例,以随机数字表法将患者分为对照组与观察组,每组51例,对照组患者采取临床常规治疗,观察组患者采取常规治疗结合补肾健脾通络方治疗.观察各组数据:治疗总有效率、治疗前后患者中医证候总积分变化及Fried表型衰弱量表(frailty phenotype,FP)评分变化及白介素-6(interleukin 6,IL-6)、超敏C反应蛋白(C-ReactiveProtein,hs-CRP)水平变化、握力变化及起立-行走计时测试(Timed Up and Go test,TUG)变化、5次坐立试验(five-times-sit-to-stand test,FTSST)变化、步速变化、体质指数(Body Mass Index,BMI)变化及四肢骨骼肌质量指数(appendicular skeletal muscle mass index,ASMI)变化、简易精神状态评分(Mini-mental State Examination,MMSE)变化、匹兹堡睡眠指数(Pittsburgh sleep quality index,PSQI)评分变化、日常生活能力(Activity of Daily Living,ADL)评分变化、微型营养评估(mini nutritionaal assessment,MNA)评分变化、患者治疗满意度、不良反应.结果 观察组患者治疗总有效率比对照组高[96.08%(49/51)vs84.31%(43/51)],P<0.05;治疗前,各组患者中医证候总积分、FP评分、IL-6、hs-CRP水平、握力、TUG测试结果及FTSST测试结果、步速、BMI、ASMI、MMSE评分、PSQI评分、ADL评分、MNA评分比较,P>0.05,治疗后各组患者中医证候总积分、FP评分、IL-6、hs-CRP水平、握力、TUG测试结果及FTSST测试结果、步速、BMI、ASMI、MMSE评分、PSQI评分、ADL评分、MNA评分均改善,观察组患者治疗后中医证候总积分、FP评分、IL-6、hs-CRP水平、握力、TUG测试结果及FTSST测试结果、步速、BMI、ASMI、MMSE评分、PSQI评分、ADL评分、MNA评分均优于对照组患者,P<0.05;观察组患者治疗满意度高于对照组[98.04%(50/51)vs84.31%(43/51)],P<0.05;观察组与对照组不良反应率均较低,且可自行缓解,P>0.05.结论 补肾健脾通络方治疗老年衰弱综合征临床疗效显著,能缓解衰弱综合征患者的临床症状,抑制患者机体炎性反应,增加肌肉质量,改善睡眠,提高生活质量,且无不良反应,较为安全可靠,值得应用.
Clinical Efficacy of Bushen Jianpi Tongluo Prescription(补肾健脾通络方)in Treatment of Frailty Syndrome in Elderly Patients
Objective To observe the clinical efficacy and safety of Bushen Jianpi Tongluo Prescription(补肾健脾通络方)in the treatment of frailty syndrome in elderly patients.Methods A total of 102 patients with senile asthenic syndrome(admitted from January 2021 to June 2022)were included in this study.The patients were divided into control group and observation group by random number table method,with 51 cases in each group.The patients in the control group received conventional clinical treat-ment,and those in the observation group received conventional treatment combined with Bushen Jianpi Tongluo Prescription.The total therapeutic response rate,the changes of patients'total TCM syndrome scores before and after treatment,the changes of fried phenotype(FP)score,interleukin-6(IL-6),high sensitive C-reactive protein(hs-CRP),grip strength change and Timed Up and Go test(TUG),5-times-Sit-to-stand test(FTSST),walking speed,body mass index(BMI)and appendicular muscle mass index(ASMI),Mini-mental State Examination(MMSE),Pittsburgh sleep quality index(PSQI)score changes,Activity of Daily Living(ADL)score changes,mini nutritionaal assessment(MNA)score changes,patients satisfaction and adverse reactions were observed.Results The total effective rate of the observation group was higher than that of the control group[96.08%(49/51)vs 84.31%(43/51)](P<0.05).Before treatment,total TCM syndrome score,FP score,the levels of IL-6 and hs-CRP,grip strength,TUG test results and FTSST test results,walking speed,BMI,ASMI,MMSE score,PSQI score,ADL score and MNA score were not significant between two groups(P>0.05).After treatment,total TCM syndrome score,FP score,the levels of IL-6 and hs-CRP,grip strength,TUG test results and FTSST test results,walking speed,BMI,ASMI,MMSE score,PSQI score,ADL score and MNA score were all improved in both groups.After treatment,the total score of TCM syndrome,FP score,the levels of IL-6 and hs-CRP,grip strength,TUG test results and FTSST test results,walking speed,BMI,ASMI,MMSE score,PSQI score,ADL score and MNA score in the observation group were better than those in the control group(P<0.05).The treatment satis-faction of the observation group was higher than that of the control group[98.04%(50/51)vs 84.31%(43/51)](P<0.05).The ADR rate of the observation group and the control group was lower,and could be alleviated by itself(P>0.05).Conclusion Bushen Jianpi Tongluo Prescription has significant clinical efficacy in the treatment of senile asthenic syndrome,which can relieve the clinical symptoms of patients with asthenic syndrome,inhibit the inflammatory response of patients,increase muscle mass,im-prove sleep and improve the quality of life,and has no adverse reactions.It is safe and reliable,worthy of application.
frailty syndromeBushen Jianpi Tongluo Prescription(补肾健脾通络方)clinical effectsquality of lifeTCM syndrome score