首页|补肾调周法联合地屈孕酮片预防子宫内膜息肉宫腔镜术后复发的临床研究

补肾调周法联合地屈孕酮片预防子宫内膜息肉宫腔镜术后复发的临床研究

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目的 研究补肾调周法联合地屈孕酮片对肾虚血瘀型子宫内膜息肉(Endometrial polyp,EP)患者宫腔镜术后复发的影响。方法 将宫腔镜术后病理明确为EP且符合中医辨证为肾虚血瘀证的60名患者,使用随机数字表法分成试验组和对照组,每组30例,对照组口服地屈孕酮片;试验组在对照组的基础上加用补肾调周法。对比治疗前两组EP的直径、雌激素受体(estrogen receptor,ER)和孕激素受体(progesterone receptor,PR)的平均光密度值,以及治疗后两组EP复发情况、子宫内膜厚度以及中医证候积分。结果 (1)ER的平均光密度值:两组间差异无统计学意义(P>0。05);(2)PR的平均光密度值:两组间差异无统计学意义(P>0。05);(3)EP的直径:两组间差异无统计学意义(P>0。05);(4)复发率:试验组与对照组复发率差异无统计学意义(P>0。05);(5)子宫内膜厚度:治疗后试验组子宫内膜厚度低于对照组,差异有统计学意义(P<0。05);(6)中医证候积分:治疗后试验组中医证候积分低于对照组,差异具有统计学意义(P<0。05);(7)中医证候疗效:治疗后,试验组总有效率为89。66%(26/29),对照组总有效率为66。67%(20/30),差异有统计学意义(P<0。05)。结论 补肾调周法联合地屈孕酮片在肾虚血瘀型EP患者宫腔镜术后能有效降低子宫内膜厚度,还可改善患者症状,降低中医证候积分。
Clinical Study of Method of Tonifying Kidney and Regulating Menstrual Cycle Combined with Dydrogesterone Tablets to Prevent Recurrence of Endometrial Polyps after Hysteroscopy
Objective To study the effect of tonifying kidney and regulating menstrual cycle combined with Dydrogesterone Tablets on the recurrence of endometrial polyps(EP)in patients with kidney deficiency and blood stasis syndrome after hysteros-copy.Methods A total of 60 patients with EP after hysteroscopy who were confirmed to be EP by pathology and conformed to tra-ditional Chinese medicine(TCM)syndrome differentiation as kidney deficiency and blood stasis syndrome were divided into a treatment group and a control group by random number table method,30 cases in each group,and the control group was given Dydrogesterone Tablets.On the basis of the control group,the treatment group was supplemented with the method of tonifying kid-ney and regulating menstrual cycle.The diameter of EP,the average optical density of estrogen receptor(ER)and progesterone receptor(PR)before treatment,the recurrence of EP,endometrial thickness and TCM syndrome scores of the two groups after treatment were compared.Result(1)The average optical density of ER:There was no significant difference between the two groups(P>0.05).(2)The average optical density value of PR:There was no statistical significance between the two groups(P>0.05).(3)The diameter of EP:There was no significant difference between the two groups(P>0.05).(4)Recurrence rate:There was no significant difference in the recurrence rate between the treatment group and the control group(P>0.05).(5)Endometrial thickness:After treatment,the endometrial thickness of the treatment group was lower than that of the control group,and the difference was statistically significant(P<0.05).(6)TCM syndrome score:After treatment,the TCM syndrome scores in the treatment group were lower than those in the control group,and the difference was statistically significant(P<0.05).(7)The efficacy of TCM syndrome:After treatment,the total effective rate was 89.66%(26/29)in the treatment group,and that was 66.67%(20/30)in the control group.There was statistical significance(P<0.05).Conclusion The Tonifying kidney and regulating menstrual cycle method combined with Dydrogesterone Tablets can effectively reduce endometrial thickness after hysteroscopy in EP patients with kidney deficiency and blood stasis syndrome and can also improve patients'symptoms and reduce TCM syndrome scores.

tonifying kidney and regulating menstrual cyclekidney deficiency and blood stasis syndromeendometrial pol-ypsrecurrence

李英焕、龙娜、张静、窦永灵、谭雅婷、韩璐、葛佳庆、麦尔哈巴·艾尼瓦尔、刘娜

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新疆医科大学,新疆乌鲁木齐 830054

深圳市宝安区妇幼保健院,广东深圳 518100

新疆医科大学第四临床医学院,新疆乌鲁木齐 830099

补肾调周法 肾虚血瘀证 子宫内膜息肉 复发

新疆维吾尔自治区自然科学基金项目新疆医科大学附属中医医院院级项目新疆医科大学研究生创新创业项目

2016D01C153ZYY201525CXCY2021024

2024

中华中医药学刊
中华中医药学会 ,辽宁中医药大学

中华中医药学刊

CSTPCD北大核心
影响因子:1.007
ISSN:1673-7717
年,卷(期):2024.42(2)
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