中华中医药学刊2024,Vol.42Issue(3) :24-35.DOI:10.13193/j.issn.1673-7717.2024.03.005

岗梅化学成分、药理作用及质量控制的研究进展

Modern Research Progress on Chemical Constituents,Pharmacological Action,Quality Control for Gangmei(Radix et Caulis Ilicis Asprellae)

蔡家瀚 翁浪仁 齐英 何子骥 沈志滨 王秋红
中华中医药学刊2024,Vol.42Issue(3) :24-35.DOI:10.13193/j.issn.1673-7717.2024.03.005

岗梅化学成分、药理作用及质量控制的研究进展

Modern Research Progress on Chemical Constituents,Pharmacological Action,Quality Control for Gangmei(Radix et Caulis Ilicis Asprellae)

蔡家瀚 1翁浪仁 1齐英 1何子骥 1沈志滨 1王秋红2
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作者信息

  • 1. 广东药科大学中药学院,广东广州 510006
  • 2. 广东药科大学中药学院,广东广州 510006;黑龙江中医药大学教育部北药基础与应用研究重点实验室/黑龙江省中药及天然药物药效物质基础研究重点实验室,黑龙江哈尔滨 150040
  • 折叠

摘要

岗梅为冬青属植物梅叶冬青的干燥根及茎,是岭南凉茶的主要原料之一.其化学成分以三萜、酚酸、多糖、挥发油等为主,具有抗炎解热镇痛、抗病原微生物、抗肿瘤、抗补体、抗溃疡、抗阿尔茨海默病等广泛药理作用,具有极高的药用和经济价值,然其质量标准和质量评价研究存在诸多不足.在对其化学成分、药理作用、质量研究进行归纳概述的基础上,根据质量标志物(Quality marker,Q-marker)理论,从成分特有性、变化性、有效性、可测性四个方面对岗梅的质量标志物进行分析与讨论,认为岗梅的三萜类和酚酸类成分可作为岗梅的质量标志物,以期为岗梅质量评价体系的规范与完善提供参考.

Abstract

Gangmei(Radix et Caulis Ilicis Asprellae)is the dried root and stem of Meiyedongqing[Ilex asprella(Hook.et Am.)Champ.Ex Benth],and it is one of the main raw materials of Lingnan herbal tea.Its chemical constituents are mainly trit-erpenes,phenolic acids,polysaccharides and volatile oils,and it has a wide range of pharmacological effects,such as anti-inflam-mation and analgesia,anti-pathogenic microorganisms,anti-tumor,anti-complement,anti-ulcer and so on.However,there are many deficiencies in the research of quality standard and quality evaluation.On the basis of summarizing its chemical compo-sitions,pharmacological action and quality study,and according to the theory of quality markers(Q-marker),the quality markers of Gangmei(Radix et Caulis Ilicis Asprellae)were analyzed and discussed from four aspects:specificity,variability,effectiveness and testability.It is considered that the triterpenes and phenolic acids of Gangmei(Radix et Caulis Ilicis Asprellae)can be used as Q-markers of Gangmei(Radix et Caulis Ilicis Asprellae)in order to provide reference for the standardization and improve-ment of the quality evaluation system of Gangmei(Radix et Caulis Ilicis Asprellae).

关键词

岗梅/化学成分/药理作用/质量控制/质量标志物

Key words

Gangmei(Radix et Caulis Ilicis Asprellae)/chemical constituents/pharmacological action/quality evaluation/quality markers

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基金项目

国家重点研发计划中医药现代化研究重点专项(2018YFC17007100)

国家自然科学基金面上项目(8177141630)

广东省重点领域研发计划(2020B11111120002)

出版年

2024
中华中医药学刊
中华中医药学会 ,辽宁中医药大学

中华中医药学刊

CSTPCD北大核心
影响因子:1.007
ISSN:1673-7717
参考文献量97
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