Pharmacological Effects of Roucongrong(Cistanches Herba)and Its Research Progress in Central Nervous System Diseases
Roucongrong(Cistanches Herba)is the fleshy stem of the Ledanaceae plant Rucongrong(Cistanche deserticola),also known as golden bamboo shoot,goblins and Dayun.The extract of Roucongrong(Cistanches Herba)mainly includes total glycosides of Roucongrong(Cistanches Herba),phenylethanoid glycosides,iridoids,volatile components,lignans,polysaccharides,alkaloids,etc.The functions of Roucongrong(Cistanches Herba)include tonifying kidney and Yang,loosing the bowel to relieve constipation,female infertility,nourishing and strengthening body,etc.The modern pharmacological effects include antioxidant,anti-apoptotic,regulating autophagy,enhancing physical strength and anti-fatigue and improving learning and cognitive func-tions.Related studies have shown that Roucongrong(Cistanches Herba)has good therapeutic effects on central nervous system diseases.Cerebral ischemia reperfusion injury(CIRI)often occurs with cerebral edema,disruption of the blood-brain barrier,neuroinflammation and neuronal apoptosis.Total glycosides of Roucongrong(Cistanches Herba)extract can inhibit inflammation and apoptosis of nerve cells,reduce the area of cerebral infarction and have neuroprotective effects on CIRI model rats.Roucon-grong(Cistanches Herba)improves the learning memory ability of Alzheimer's disease(AD)and vascular dementia(VaD)model rats by reducing free radical accumulation and inhibiting oxidative stress and inflammatory response.Roucongrong(Cistanches Herba)can improve abnormal motor behavior and exert neuroprotective effects in Parkinsons disease(PD)mice.Roucongrong(Cistanches Herba)can inhibit the levels of excitatory amino acids in amyotrophic lateral sclerosis(ALS),reduce the neurotoxic effects,alter astrocyte function and improve neuronal survival.At present,Roucongrong(Cistanches Herba)has been widely used in central nervous system diseases.In this paper,the pharmacological effects and research progress of Roucongrong(Cistanches Herba)in central nervous system diseases are reviewed in order to provide new ideas for the development and utilization of Rou-congrong(Cistanches Herba).
Roucongrong(Cistanches Herba)central nervous system diseasescerebrovascular diseaseneurodegenerative disease
万方数据
维普
