Research Progress on Reproductive Functions of Dongchongxiacao(Cordyceps sinensis)and Its Components
Dongchongxiacao(Cordyceps sinensis,CS)is a traditional Chinese medicinal herb known for its tonic properties,and it has been used for centuries to enhance reproductive activity and restore the damaged reproductive function.The compo-nents of CS are complex,and its main extraction components include cordycepin,isoflavones obtained from CS(CSIF),and CS water extraction components F1(water-soluble polysaccharide),F2(water-soluble protein)and F3(poor water-soluble poly-saccharide and protein).Despite its widespread use,there is currently no systematic review of the effects,mechanisms,and clini-cal applications of CS and its components on reproductive function.This paper is the first to comprehensively review the in vitro and in vivo effects and mechanisms of CS and its components on the production of male and female reproductive steroids.In the female reproductive system,CS promotes the production of estradiol(E2)in human granulosa luteal cells(GLC)by up-regula-ting the expression of steroidogenesis acute regulator protein(StAR)and aromatase(AROM).In addition,oral administration of CSIF extracted from CS exhibits the significant estrogenic effects in OVX rats.In the male reproductive system,CS and its differ-ent components not only have a positive effect on testosterone production in primary mouse Leydig cells and progesterone genera-tion in mouse Leydig tumor cells(MA-10 cells),but also significantly increase the plasma testosterone levels in mice.This study not only provides new research directions for investigating the regulation of reproductive function by CS and its applications in assisted reproductive technologies,but also offers the novel clinical treatment strategies.
Dongchongxiacao(Cordyceps sinensis)reproductive functionsreproductive steroidsin vivo effectsin vitro effects
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