Clinical Efficacy of Bushen Huoxue Decoction(补肾活血汤)Assisted with VAD in Treatment of Renal Impairment of Multiple Myeloma and Its Effects on Bone Metabolism and Renal Function
Objective To investigate the clinical efficacy of Bushen Huoxue Decoction(补肾活血汤)in assisting vincristine+doxorubicin+dexamethasone(VAD)in the treatment of renal damage caused by multiple myeloma and dynamically observe the effects of this treatment on bone metabolism and renal function.Methods A total of 88 patients diagnosed with multiple myeloma and accompanied by renal damage from January 2019 to January 2021 were selected as the research subjects,and they were e-qually divided into the observation group and the control group by the random number method.The control group was given VAD treatment,and the observation group was additionally given Bushen Huoxue Decoction on the basis of the control group.The differences of clinical effects after four courses of treatment were compared between the two groups.The differences of bone me-tabolism indexes and renal function indexes were compared before treatment and after two and four courses of treatment.Results The total effective rate(90.9％)in the observation group was significantly higher than that(75.0％)in the control group,and the difference was statistically significant(P＜0.05).With the prolongation of treatment time,the main symptoms,secondary symptoms and the total score in the two groups were gradually decreased(P＜0.05).After two and four courses of treatment,the main symptoms,secondary symptoms and total scores of the observation group were lower than those of the control group(P＜0.05).With the prolongation of treatment,the levels of the receptor activator of nuclear factor-κB ligand(RANKL)of patients in the two groups gradually were decreased(P＜0.05),while the levels of alkaline phosphatase(ALP)and osteocalcin(OCN)were gradually increased(P＜0.05).After two and four courses of treatment,the level of RANKL of the observation group was lower than that of the control group(P＜0.05),while the levels of ALP and OCN of the observation group were higher than those of the control group(P＜0.05).With the prolongation of treatment time,the levels of serum creatinine(Scr),β2 mi-croglobulin(β2-MG),neutrophil gelatinase-associated lipocalin(NGAL),kidney injury molecule-1(KIM-1),Cystatin C(Cys-C)and urinary micro-albumin(mAlb)in patients of the two groups were gradually decreased(P＜0.05).After two and four courses of treatment,the levels of Scr,β2-MG,NGAL,KIM-1,Cys-C and urinary mAlb in the observation group were lower than those in the control group(P＜0.05).Conclusion Bushen Huoxue Decoction assisted VAD in the treatment of multi-ple myeloma renal impairment has a more significant clinical effect,which can better improve the symptoms and regulate the bone metabolism and more effectively reverse the renal impairment.
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