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小驳骨化学成分与生物活性的研究进展

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小驳骨为爵床科药用植物，具有祛瘀止痛、续筋接骨的功效，长期以来被用于跌打损伤、筋伤骨折、风湿骨痛、血瘀经闭和产后腹痛等疾病的治疗。通过搜索中国知网、PubMed、Web of Science等数据库，查找国内外已经发表的小驳骨相关文献，对小驳骨近二十年的化学成分和生物活性研究进行系统地梳理、归纳，发现目前已从小驳骨中分离出超过100种化合物，包括萜类、黄酮类、苯丙素类、木质素类、香豆素类和生物碱等。小驳骨提取物具有显著的生物活性，如抗炎、抗氧化等，其抗炎作用机制可能与调节炎症因子水平、抑制相关信号通路或相关蛋白表达等有关。可为小驳骨资源后续深入系统地研究和临床开发提供科学依据和理论参考。
Research Progress on Chemical Constituents and Bioactivities of Xiaobogu(Justicia gendarussa)
Xiaobogu(Justicia gendarussa)is a medicinal plant belonging to the family of Acanthaceae,and has the functions of removing blood stasis and relieving pain,reinforcing tendons and bones.It has long been used for the treatment of various dis-eases,such as bruises,fractures,rheumatism,bone pain,blood stasis and postpartum abdominal pain.In this paper,CNKI,Pubmed,Web of Science and other databases were searched for domestic and foreign published literatures related to Xiaobogu(Justicia gendarussa),and the chemical components of Xiaobogu(Justicia gendarussa)and bioactivity studies in the past twenty years were systematically combed and summarized.It was found that a total of more than 100 compounds have been isolated from Xiaobogu(Justicia gendarussa),including terpenoids,flavonoids,phenylpropanoids,lignins,coumarins and alkaloids.The extract of Xiaobogu(Justicia gendarussa)has significant bioactivities,such as anti-inflammatory and antioxidant.Its mechanism may be related to regulating the levels of inflammatory factors,inhibiting related signaling pathways or related protein expressions.This paper can provide theoretical reference and scientific basis for further systematic research and clinical development of Xiaobogu(Justicia gendarussa)resources.

Xiaobogu(Justicia gendarussa)chemical constituentsbioactivityresearch progress

舒朋华、李念慈、赵秋悦、刘光伟、杨远、张慧、蔡舒静、臧硕、孙娜

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许昌学院食品与药学院,河南许昌 461000

小驳骨 化学成分 生物活性 研究进展

国家自然科学基金青年科学基金河南省科技攻关计划河南省高等学校青年骨干教师培养计划河南省高等学校重点科研项目河南省高等学校重点科研项目国家级大学生创新创业训练计划河南省大学生创新创业训练计划河南省大学生创新创业训练计划许昌学院校级科研创新团队项目许昌学院大学生创新创业训练计划

217021782121023110312021GGJS14422A35000923A3500122022104800082022104800202022104800212022CXTD007X202210480016

2024

10.13193/j.issn.1673-7717.2024.03.023

中华中医药学刊
中华中医药学会 ,辽宁中医药大学

中华中医药学刊

CSTPCD北大核心
影响因子：1.007
ISSN：1673-7717
年,卷(期)：2024.42(3)
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