Research and Discussion on Modern Mechanism of Traditional Chinese Medicine in Treatment of Prostate Cancer
Prostate cancer has become a serious threat to the health of middle-aged and elderly men in the world and is one of the most common middle-aged and elderly male malignant tumors,accounting for one tenth of male tumors.Studies have found that traditional Chinese medicine plays an important role in the intervention of anti-prostate cancer.This article reviewed the research progress on the modern mechanism of traditional Chinese medicine in the treatment of prostate cancer in recent years.Through the etiology and pathogenesis of prostate cancer in traditional Chinese medicine,the related pathway mechanism[phosphatidylinositol-3-kinase(PI3 K)/protein kinase AKT/rapamycin target protein(mTOR)signaling pathway,nuclear transcription factor-κB signaling pathway,Notch signaling pathway,secretory glycoprotein(Wnt)/β-catenin signaling pathway,transforming growth factor-β/Smads signaling pathways and androgen receptors(AR)],the effective components of traditional Chinese medicine(curcumin,quercetin,honokiol,polyphyllin I),single Chinese medicine[Longkui(Herba Solani Nigri),Baihua-sheshecao(Herba Hedyoti Diffusae),Lingzhi(glossy ganoderma),Yiyiren(Coicis Semen)and traditional Chinese medicine com-pound[TCM-1,CFF-1,Zhou's Qiling Formula(周氏芪凌方),Xihuang Pill(西黄丸)]on the intervention of prostate cancer.This study demonstrated the unique advantages of traditional Chinese medicine in the treatment of prostate cancer,in order to pro-vide a basis for the further exploration of basic research and clinical practice of traditional Chinese medicine against prostate canc-er.
prostate cancermechanism researchactive ingredientChinese medicine compoundChinese medicine
万方数据
维普
