首页|T细胞亚群平衡在心力衰竭中的作用与中医药干预研究进展

T细胞亚群平衡在心力衰竭中的作用与中医药干预研究进展

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心力衰竭是各种心脏疾病的严重和终末阶段,随着对心力衰竭的病理生理机制研究不断深入,越来越多的证据表明T淋巴细胞亚群激活参与了心衰的发生发展,各种刺激导致效应T细胞的活化,渗透心血管壁,促进血管衰老、弹性层膜降解以及心肌纤维化,导致心血管结构和功能改变。中医药通过调节T细胞亚群平衡,减轻炎症反应,维持免疫内环境稳定,进而缓解临床症状和体征,提高心功能和运动耐量,改善生活质量,在临床上应用越来越广泛。重点对T细胞亚群平衡在心衰中的作用及中药有效成分、单味中药、中药复方、中成药以及针灸的治疗进行概述,为中医药在心力衰竭免疫领域的研究提供依据。
Research Progress on Role of T Lymphocyte Subsets Balance in Heart Failure and Intervention of Traditional Chinese Medicine
Heart failure is the severe and terminal stage of various heart diseases.With the deepening of the research on the pathophysiological mechanism of heart failure,more and more evidences show that the activation of T lymphocyte subsets is in-volved in the occurrence and development of heart failure.Various stimuli lead to the activation of effector T cells,which penetrate the vascular wall and promote vascular aging,elastic layer degradation and myocardial fibrosis,leading to changes in cardiovascu-lar structure and function.By regulating the balance of T cell subsets,reducing inflammation,maintaining the stability of the im-mune home environment,and then relieving clinical symptoms and signs,improving cardiac function and exercise tolerance,and improving the quality of life,traditional Chinese medicine(TCM)is more and more widely used in clinical practice.This article focuses on the role of T cell subset balance in heart failure and the treatment of active ingredients of TCM,single Chinese medi-cine,compound,patent medicine and acupuncture.It provides a basis for the research of traditional Chinese medicine in the field of heart failure immunity.

heart failureT cell subsettraditional Chinese medicinereview

卫靖靖、乔利杰、王新陆、李彬、李兴渊、于瑞、王永霞、朱明军

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河南中医药大学,河南郑州 450000

河南中医药大学第一附属医院,河南郑州 450000

心力衰竭 T细胞亚群 中医药 综述

国家重点研发计划重点专项国家重点研发计划重点专项国家自然科学基金重点项目河南省中医药科学研究专项

2019YFC17100002019YFC1710003820301202018JDZX009

2024

中华中医药学刊
中华中医药学会 ,辽宁中医药大学

中华中医药学刊

CSTPCD北大核心
影响因子:1.007
ISSN:1673-7717
年,卷(期):2024.42(3)
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