首页|上海市某方舱医院2897例新型冠状病毒Omicron变异株轻型/无症状感染者住院时间影响因素分析

上海市某方舱医院2897例新型冠状病毒Omicron变异株轻型/无症状感染者住院时间影响因素分析

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目的 探讨上海市某方舱医院新型冠状病毒奥密克戎(Omicron)变异株轻型/无症状感染者住院时间的影响因素。方法 回顾性收集上海宝山泾灿路(罗泾京东)方舱医院收治的2897例Omicron变异株轻型/无症状感染者的病历资料,分析其一般资料、住院时间等基本情况,探究不同特征的新冠病毒Omicron变异株感染者住院时间差异,采用多重线性回归方法分析住院时间的影响因素。根据单因素分析结果,采用二元logistic回归分析住院时间≥14 d可能的影响因素。结果 2897例Omicron变异株轻型/无症状感染者的平均住院时间为(9。1±4。6)d,不同年龄段、入舱前核酸阳性时间以及伴有咳嗽、咳痰、咽痛、发热、流涕、鼻塞、口干咽燥、头痛、乏力、肌痛、腹泻、恶寒、恶心呕吐、头晕症状的感染者住院时间不同,差异具有统计学意义(P<0。05)。多重线性回归结果显示,年龄增加、患有糖尿病史以及咽痛、发热、流涕、肌痛症状会增加住院天数,而入舱前核酸阳性时间长则会减少住院天数。住院时间≥14 d者,高龄、糖尿病史以及出现咽痛、发热、口干咽燥、肌痛、恶心呕吐症状的占比更高,入舱前核酸阳性时间相对更短,接种2针及以上疫苗占比更低,差异具有统计学意义(P<0。05)。二元Logistic回归结果显示,高龄、入舱前核酸阳性时间短、糖尿病史以及发热和口干咽燥症状可能是导致住院时间超过14 d的危险因素,接种2针及以上疫苗可能是保护因素。结论 Omicron变异株轻型/无症状感染者平均住院时间约为9d,高龄、疫苗接种2针及以上、患有糖尿病史、入舱前核酸阳性时间短以及咽痛、发热、流涕、口干咽燥、肌痛等正气虚衰、病邪入里、化热伤阴表现对于住院时间可能产生重要影响。通过尽早识别核酸转阴慢、住院时间长的高危患者,以期为缩短核酸转阴时间、指导重点人群精准防控提供指导方向。
Analysis of Influencing Factors Related to Hospitalization Time of 2897 SARS-CoV-2 Omicron Variant Patients with Mild Symptoms/Asymptomatic Infection in A Cabin Hospital in Shanghai
Objective To explore the influencing factors related to the hospitalization time of SARS-CoV-2 Omicron variant patients with mild symptoms/asymptomatic infection in a cabin hospital in Shanghai.Methods The data of 2897 SARS-CoV-2 Omicron variant patients with mild symptoms/asymptomatic infection admitted to the Shanghai Jingcan Road(Luojing Jingdong)cabin hospital was retrospectively collected.The general information,hospitalization time and its difference according to different characteristics were analyzed.Multiple linear regression analysis was used to explore the influencing factors of hospitalization time.Based on the results of univariate analysis,the binary logistic regression analysis was used to figure out the possible influen-cing factors when hospitalization time was greater than 14 days.Results The average hospitalization time of 2897 SARS-CoV-2 Omicron variant patients with symptoms/asymptomatic infections was(9.1±4.6)days.The hospitalization time of infected in-dividuals with different ages,positive nucleic acid test results before entering the cabin,and accompanying symptoms including cough,sputum,sore throat,fever,runny nose,nasal congestion,dry mouth and throat,headache,fatigue,muscle pain,diarrhea,chills,nausea and vomiting,and dizziness varies,and the differences were statistically significant(P<0.05).Multiple linear re-gression analysis showed that the hospitalization time would increase when patients had advanced age,diabetes,and sore throat,fe-ver,runny nose and myalgia,but shorten with longer onset time.Those who had been hospitalized for more than 14 days had a higher proportion of the elderly,diabetes history and symptoms of sore throat,fever,dry mouth and dry throat,myalgia,nausea and vomiting.The onset time was relatively shorter,and the proportion of vaccinations of 2 doses or more was lower,with significant difference(P<0.05).The results of binary logistic regression analysis showed that advanced age,short onset time,diabetes,fe-ver,and dry mouth and throat symptoms may be the risk factors leading to more than 14 days of hospitalization,and vaccination of two or more shots may be protective factors.Conclusion The average hospitalization time for Omicron variant mild/asymptomatic infections is about 9 days.The advanced age,two or more shots of vaccination,diabetes and short onset time may influence the hospitalization time,as well as symptoms with deficiency of vital Qi,pathogens invading the interior,exuberant heat consuming Yin fluid,such as sore throat,fever,runny nose,dry mouth and throat,myalgia,etc.It is suggested to identify high-risk patients with slow nucleic acid conversion tine and long hospitalization time early to provide guidance for shortening the time of nucleic acid conversion and precise prevention for risk group.

severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)corona virus disease 2019(COVID-19)Omicron varianthospitalization timecabin hospitaltraditional Chinese medicine

梁元钰、吕晓东、袁佺、庞立健、臧凝子、王梅、姜扬、刘创、张浩洋、王佳然

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辽宁中医药大学,辽宁沈阳 110847

辽宁中医药大学附属医院,辽宁沈阳 110032

新型冠状病毒 新冠感染 奥密克戎 住院时间 方舱医院 中医药

国家自然科学基金面上项目国家中医药管理局中医络病重点学科项目辽宁省新冠肺炎疫情防控应急科研攻关定向项目辽宁省科技厅中央引导地方科技发展基金项目

82274440T0302辽科发[2022]28号2023JH6/100100025

2024

中华中医药学刊
中华中医药学会 ,辽宁中医药大学

中华中医药学刊

CSTPCD北大核心
影响因子:1.007
ISSN:1673-7717
年,卷(期):2024.42(4)
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