Review of Traditional Chinese Medicine Intervention of Pyroptosis after Stroke
Stroke has become the second largest cause of death and disability worldwide,causing a heavy burden on individu-als,families and society.Brain cell injury and death are key factors that affect neurological function,prognosis and quality of life in stroke patients.Inflammatory response is a key pathological link in the occurrence and development of stroke.Studies have shown that cell death amplifies inflammatory reactions and exacerbates pathological and neurological damage after stroke.As a new type of pro inflammatory programmed cell death,pyroptosis plays an important role in the course of stroke.Inhibiting pyropto-sis might regulate the process of brain cell injury and death,playing a neuroprotective role.There are unique advantages such as multi-pathway,multi-target points and fewer side effects in traditional Chinese medicine(TCM)prevention and treatment of stroke,in addition,the curative effect is remarkable.The research on the mechanism of TCM regulating pyroptosis is a new hots-pot in this field.Based on relevant research at home and abroad,this article summarized the overview of cell death,mechanism of action,signal pathways,application in stroke treatment and research on TCM based on cell death,providing new ideas for further improving the efficacy of TCM in treating stroke.
pyroptosisstrokeintracerebral hemorrhageischemic stroketraditional Chinese medicine
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