Research Progress in Pharmacological Studies of Buguzhi(Psoraleae Fructus)
Buguzhi(Psoraleae Fructus)is a commonly used and important Chinese medicine,mainly for the treatment of oste-oporosis,and is the prescription ingredient of many traditional Chinese medicine(TCM)prescriptions.According to modern phar-macological research,more than 30 kinds of chemical components,such as coumarins,flavonoids,monoterpenoid phenols and benzofurans,have been isolated and identified from Buguzhi(Psoraleae Fructus),so as to realize the role of Buguzhi(Psoraleae Fructus).A large number of in vivo and in vitro experimental studies have shown that Buguzhi(Psoraleae Fructus)has a wide range of pharmacological effects,including antibacterial,anti-tumor,anti-viral,anti-oxidation,anti-osteoporosis,increasing skin pigment and enhancing the body's immune function.A few chemical components of Buguzhi(Psoraleae Fructus)were detec-ted,indicating that the potential pharmacological activity and clinical application value of Buguzhi(Psoraleae Fructus)still need further research.Buguzhi(Psoraleae Fructus)can also cause hepatotoxicity by affecting liver regeneration,oxidative stress,bile acid balance and mitochondrial dysfunction,etc.With increasing reports of hepatotoxicity caused by Buguzhi(Psoraleae Fructus)and its compound preparations,the hepatotoxicity of Buguzhi(Psoraleae Fructus)has also attracted extensive attention.The re-search direction and application prospect of Buguzhi(Psoraleae Fructus)were reviewed by reviewing relevant literatures at home and abroad,starting from the pharmacological action and toxicity of Buguzhi(Psoraleae Fructus),in order to provide theoretical guidance for the comprehensive utilization of resources and further research.
traditional Chinese medicine(TCM)Buguzhi(Psoraleae Fructus)pharmacological effectsresearch progress
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