摘要
补骨脂Psoralea corilyfolia L.是一种常用的重要中药材,主要治疗骨质疏松症,是诸多中医的处方成分.根据现代药理学研究,补骨脂中分离鉴定出30余种化学成分,如香豆素类、黄酮类、单萜酚类、苯并呋喃类等,共同实现补骨脂的作用发挥.大量的体内及体外实验研究表明补骨脂具有广泛的药理作用,包括抗菌、抗肿瘤、抗病毒、抗氧化、抗骨质疏松、增加皮肤色素及增强机体免疫功能等作用.补骨脂中有少部分的化学成分进行了检测,指明补骨脂的潜在药理活性和临床应用价值仍需继续研究.补骨脂还可通过影响肝再生、氧化应激、胆汁酸平衡和线粒体功能障碍等途径引起肝毒性,伴随补骨脂及其复方制剂用药过程中引起肝毒性的报道日益增多,补骨脂的肝毒性也受到广泛关注.查阅国内外相关文献,从补骨脂的药理作用和毒性着手,综述该中药的研究方向和应用前景,以期为资源综合利用和进一步研究提供理论指导.
Abstract
Buguzhi(Psoraleae Fructus)is a commonly used and important Chinese medicine,mainly for the treatment of oste-oporosis,and is the prescription ingredient of many traditional Chinese medicine(TCM)prescriptions.According to modern phar-macological research,more than 30 kinds of chemical components,such as coumarins,flavonoids,monoterpenoid phenols and benzofurans,have been isolated and identified from Buguzhi(Psoraleae Fructus),so as to realize the role of Buguzhi(Psoraleae Fructus).A large number of in vivo and in vitro experimental studies have shown that Buguzhi(Psoraleae Fructus)has a wide range of pharmacological effects,including antibacterial,anti-tumor,anti-viral,anti-oxidation,anti-osteoporosis,increasing skin pigment and enhancing the body's immune function.A few chemical components of Buguzhi(Psoraleae Fructus)were detec-ted,indicating that the potential pharmacological activity and clinical application value of Buguzhi(Psoraleae Fructus)still need further research.Buguzhi(Psoraleae Fructus)can also cause hepatotoxicity by affecting liver regeneration,oxidative stress,bile acid balance and mitochondrial dysfunction,etc.With increasing reports of hepatotoxicity caused by Buguzhi(Psoraleae Fructus)and its compound preparations,the hepatotoxicity of Buguzhi(Psoraleae Fructus)has also attracted extensive attention.The re-search direction and application prospect of Buguzhi(Psoraleae Fructus)were reviewed by reviewing relevant literatures at home and abroad,starting from the pharmacological action and toxicity of Buguzhi(Psoraleae Fructus),in order to provide theoretical guidance for the comprehensive utilization of resources and further research.
基金项目
教育部高等学校博士学科点专项科研基金项目(20132133110006)
NETL
NSTL
万方数据