首页|玉屏风散的研究进展及质量标志物预测分析

玉屏风散的研究进展及质量标志物预测分析

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玉屏风散为扶正固本的经典名方,主治表虚自汗证,具有抗肿瘤、抗炎、抗菌、抗病毒、调节免疫作用等药理作用,现代临床多用于治疗感冒、过敏性鼻炎、支气管哮喘、肺炎、肾病综合征、慢性肾炎等。总结了近年来玉屏风散的化学成分、药理作用和临床应用,并基于中药质量标志物(Q-Marker)"五原则"对玉屏风散的质量标志物进行预测分析,揭示升麻素、5-O-甲基维斯阿米醇苷、汉黄芩素、槲皮素、山柰酚、亥茅酚苷、芒柄花素、白术内酯Ⅰ-Ⅲ、黄芪皂苷Ⅰ-Ⅱ、毛蕊异黄酮、毛蕊异黄酮-7-O-β-D-葡萄糖苷、β-谷甾醇、黄苓素、大豆皂苷、黄芪皂苷Ⅳ、异黄芪皂苷Ⅰ-Ⅱ、β-香树脂醇、异紫花前胡内酯可作为玉屏风散的质量标志物,可为建立玉屏风散复方制剂的质量控制体系提供科学参考依据。
Research Progress of Yupingfeng Powder(玉屏风散)and Predictive Analysis on Quality Markers(Q-Marker)
Yupingfeng Powder(玉屏风散)is a classic prescription for strengthening the body and strengthening the founda-tion.It is mainly used to treat the syndrome of self sweating due to the exterior deficiency.It has pharmacological effects such as anti-tumor,anti-inflammatory,antibacterial,antiviral and immune regulating effects.Modern clinical practice mostly uses it to treat colds,allergic rhinitis,bronchial asthma,pneumonia,nephrotic syndrome,chronic nephritis and so on.This article summa-rized the chemical composition,pharmacological effect and clinical application of Yupingfeng Powder in recent years,and predic-ted and analyzed the quality markers of Yupingfeng Powder based on the"five principles"of traditional Chinese medicine quality markers(Q-marker),revealing that cimifugin,4'-O-β-D-glucosyl-5-O-methylvisamminol,wogonin,quercetin,kaempferol,sec-O-glucosylhamaudol,formononetin,atractylenolide Ⅰ-Ⅲ,astragaloside Ⅰ-Ⅱ,calyosin,calyosin-7-O-β-D-glucoside,β-sitosterol,baicalein,soyasaponin,astragaloside Ⅳ,isostragaloside Ⅰ-Ⅱ,β-amyrin and marmesinin could be used as Q-markers of Yupingfeng Powder,which could provide scientific reference for establishing the quality control system of Yupingfeng Powder.

Yupingfeng Powder(玉屏风散)chemical compositionpharmacological actionclinical applicationquality markers

李鹏飞、丘琴、覃春萍、莫惠晴、刘晓芳、史俊豪、古宝浚

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广西中医药大学,广西南宁 530000

广西优势中成药与民族药开发工程技术研究中心,广西南宁 530000

玉屏风散 化学成分 药理作用 临床应用 质量标志物

国家自然科学基金项目国家中医药管理局高水平中医药重点学科(壮药学)建设项目广西高等学校千名中青年骨干教师教育计划项目广西壮瑶药重点实验室项目壮瑶药协同创新中心项目广西壮族自治区民族药资源与应用工程研究中心项目广西科技基地和人才专项广西重点研发计划项目广西中医药重点学科壮药学项目广西一流学科中药学(民族药学)项目广西中医药大学"桂派杏林青年英才"培养项目

82060713国中医药人教函[2022]226号桂教教师[2022]60号桂科基字[2014]32号桂教科研[2013]20号桂发改高技函[2020]2605号桂科AD21238031桂科AB21196016GZXK-Z-20-64桂教科研[2018]12号2022C032

2024

中华中医药学刊
中华中医药学会 ,辽宁中医药大学

中华中医药学刊

CSTPCD北大核心
影响因子:1.007
ISSN:1673-7717
年,卷(期):2024.42(4)
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