Experiment and Mechanism of Zhigancao Decoction(炙甘草汤)in Prevention and Treatment of Cardiovascular Diseases
Cardiovascular disease is a major public health problem worldwide,and its incidence rate and mortality remain high.Zhigancao Decoction(炙甘草汤)is a famous prescription for treating palpitations by Zhongjing,and has been widely used in the prevention and treatment of various cardiovascular diseases through the practice and expansion of modern physicians.A large amount of evidence from multiple animal and cellular experimental studies shows that Zhigancao Decoction can prevent and treat cardiovascular diseases from three main aspects:anti atherosclerosis,anti myocardial fibrosis and anti arrhythmia.①It can inhibit inflammatory reaction,reduce oxidative stress,protect vascular endothelium and prevent and treat ischemic cardiomyopa-thy.②By reducing the concentrations of procollagen type Ⅰ(PC Ⅰ)and procollagen type Ⅲ(PC Ⅲ)in myocardial tissue,regu-lating nuclear factor(NF)-κB signal pathway and other pathways,it can inhibit myocardial fibrosis.③It can act on multiple ion channels such as sodium current(INa),L-type calcium current(ICaL),fast delayed rectifier potassium current(Ikr)and instanta-neous outward potassium current(Ito).It prolongs the action potential duration of myocardial cells and reduces the action poten-tial amplitude.It can alleviate the degree of myocardial injury after ischemia reperfusion by regulating the PI3K/Akt/mTOR sig-nal pathway.Therefore,it effectively reduces the occurrence of arrhythmia and improves the severity of the attack.
cardiovascular diseaseZhigancao Decoction(炙甘草汤)mechanism researchexperimental study
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