中药多糖治疗化疗性骨髓抑制的药理作用研究进展
Mechanism of TCM Polysaccharides in Treatment of Chemotherapeutic Myelosuppression:A Review
张江涛 1谢欣序 1崔亚茹 1余军2
作者信息
- 1. 江西中医药大学,江西南昌 330004
- 2. 天普大学路易斯卡茨医学院,费城PA19140,美国
- 折叠
摘要
化疗性骨髓抑制是癌症化疗引起的最常见不良反应之一,临床表现为外周血细胞数量减少、机体免疫力下降、感染风险增加等,严重影响癌症患者的治疗周期.临床上缓解骨髓抑制的常用药物如粒细胞集落刺激因子(Granulocyte colony-stimulating factor,G-CSF),虽短期内能够快速恢复外周粒细胞数量,但由于其诱导产生的中性粒细胞成熟度不足、损害先天免疫等问题,并不能有效的降低感染风险或者从本质上改善造血系统的损伤.中药多糖来源广泛、安全性高,并且具有调节机体免疫、促造血、抗氧化等多种药理作用,表现出较好地抗骨髓抑制的潜力.从化疗致骨髓抑制出发,首先分析阐述了化疗致机体造血系统损伤的常见机制,其次重点介绍了中药多糖改善化疗性骨髓抑制的药理作用最新研究进展,以期为治疗骨髓抑制的药物研究提供参考.
Abstract
Chemotherapeutic myelosuppression is one of the most common toxic side effects caused by chemotherapy.The clinical manifestations include decreased number of peripheral blood cells,decreased immunity and increased risk of infection,which seriously hinder the treatment.Although the commonly used drugs to relieve chemotherapeutic myelosuppression,such as granulocyte colony-stimulating factor(G-CSF)can partially restore the number of peripheral blood cells in the short term,they cannot be used in the long term due to the formation of neutrophil granules induced by G-CSF is limited,which damages innate immunity and cannot effectively reduce the risk of infection.Traditional Chinese Medicine(TCM)polysaccharide has a wide range of sources with proven safety.Studies have shown that TCM polysaccharide has many biological activities such as regulating body immunity,promoting hematopoiesis and anti-oxidation.In this paper,the mechanism of chemotherapy-induced hemato-poietic injury was analyzed from the perspective of chemotherapy-induced myelosuppression,and the latest research progress of TCM polysaccharides in improving the effect and mechanism of chemotherapy-induced myelosuppression was mainly introduced in order to provide reference for the treatment of chemotherapy-induced myelosuppression.
关键词
造血/化疗/骨髓抑制/多糖/中药多糖Key words
hematopoiesis/chemotherapy/myelosuppression/polysaccharide/TCM polysaccharides引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据