Mechanism of TCM Polysaccharides in Treatment of Chemotherapeutic Myelosuppression:A Review
Chemotherapeutic myelosuppression is one of the most common toxic side effects caused by chemotherapy.The clinical manifestations include decreased number of peripheral blood cells,decreased immunity and increased risk of infection,which seriously hinder the treatment.Although the commonly used drugs to relieve chemotherapeutic myelosuppression,such as granulocyte colony-stimulating factor(G-CSF)can partially restore the number of peripheral blood cells in the short term,they cannot be used in the long term due to the formation of neutrophil granules induced by G-CSF is limited,which damages innate immunity and cannot effectively reduce the risk of infection.Traditional Chinese Medicine(TCM)polysaccharide has a wide range of sources with proven safety.Studies have shown that TCM polysaccharide has many biological activities such as regulating body immunity,promoting hematopoiesis and anti-oxidation.In this paper,the mechanism of chemotherapy-induced hemato-poietic injury was analyzed from the perspective of chemotherapy-induced myelosuppression,and the latest research progress of TCM polysaccharides in improving the effect and mechanism of chemotherapy-induced myelosuppression was mainly introduced in order to provide reference for the treatment of chemotherapy-induced myelosuppression.
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